Improving the clinical prediction of psychosis by combining ultra-high risk criteria and cognitive basic symptoms

Schultze-Lutter, Frauke; Klosterkötter, Joachim; Ruhrmann, Stephan (2014). Improving the clinical prediction of psychosis by combining ultra-high risk criteria and cognitive basic symptoms. Schizophrenia Research, 154(1-3), pp. 100-106. Elsevier 10.1016/j.schres.2014.02.010

[img] Text
1-s2.0-S0920996414000760-main.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (330kB) | Request a copy

OBJECTIVE Cognitive impairments are regarded as a core component of schizophrenia. However, the cognitive dimension of psychosis is hardly considered by ultra-high risk (UHR) criteria. Therefore, we studied whether the combination of symptomatic UHR criteria and the basic symptom criterion "cognitive disturbances" (COGDIS) is superior in predicting first-episode psychosis. METHOD In a naturalistic 48-month follow-up study, the conversion rate to first-episode psychosis was studied in 246 outpatients of an early detection of psychosis service (FETZ); thereby, the association between conversion, and the combined and singular use of UHR criteria and COGDIS was compared. RESULTS Patients that met UHR criteria and COGDIS (n=127) at baseline had a significantly higher risk of conversion (hr=0.66 at month 48) and a shorter time to conversion than patients that met only UHR criteria (n=37; hr=0.28) or only COGDIS (n=30; hr=0.23). Furthermore, the risk of conversion was higher for the combined criteria than for UHR criteria (n=164; hr=0.56 at month 48) and COGDIS (n=158; hr=0.56 at month 48) when considered irrespective of each other. CONCLUSIONS Our findings support the merits of considering both COGDIS and UHR criteria in the early detection of persons who are at high risk of developing a first psychotic episode within 48months. Applying both sets of criteria improves sensitivity and individual risk estimation, and may thereby support the development of stage-targeted interventions. Moreover, since the combined approach enables the identification of considerably more homogeneous at-risk samples, it should support both preventive and basic research.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy > Research Division

UniBE Contributor:

Schultze-Lutter, Frauke

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0920-9964

Publisher:

Elsevier

Language:

English

Submitter:

Myriam Pyrlik

Date Deposited:

11 Sep 2014 12:03

Last Modified:

15 Dec 2014 17:16

Publisher DOI:

10.1016/j.schres.2014.02.010

PubMed ID:

24613572

Uncontrolled Keywords:

Ultra-high risk, Attenuated psychotic symptom, Basic symptom, Cognitive disturbances, Prediction, Cognition

BORIS DOI:

10.7892/boris.47249

URI:

https://boris.unibe.ch/id/eprint/47249

Actions (login required)

Edit item Edit item
Provide Feedback