Testosterone and acute stress are associated with fibrinogen and von Willebrand factor in African men: the SABPA study.

Malan, Nicolaas T.; von Känel, Roland; Schutte, Alta E.; Huisman, Hugo W.; Schutte, Rudolph; Smith, Wayne; Mels, Carina M.; Kruger, Ruan; Meiring, Muriel; van Rooyen, Johannes M.; Malan, Leoné (2013). Testosterone and acute stress are associated with fibrinogen and von Willebrand factor in African men: the SABPA study. International journal of cardiology, 168(5), pp. 4638-4642. Elsevier 10.1016/j.ijcard.2013.07.191

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BACKGROUND Low testosterone, acute and chronic stress and hypercoagulation are all associated with hypertension and hypertension-related diseases. The interaction between these factors and future risk for coronary artery disease in Africans has not been fully elucidated. In this study, associations of testosterone, acute cardiovascular and coagulation stress responses with fibrinogen and von Willebrand factor in African and Caucasian men in a South African cohort were investigated. METHODS Cardiovascular variables were studied by means of beat-to-beat and ambulatory blood pressure monitoring. Fasting serum-, salivary testosterone and citrate coagulation markers were obtained from venous blood samples. Acute mental stress responses were evoked with the Stroop test. RESULTS The African group demonstrated a higher cardiovascular risk compared to Caucasian men with elevated blood pressure, low-grade inflammation, chronic hyperglycemia (HbA1c), lower testosterone levels, and elevated von Willebrand factor (VWF) and fibrinogen levels. Blunted testosterone acute mental stress responses were demonstrated in African males. In multiple regression analyses, higher circulating levels of fibrinogen and VWF in Africans were associated with a low T environment (R(2) 0.24-0.28; p≤0.01), but only circulating fibrinogen in Caucasians. Regarding endothelial function, a low testosterone environment and a profile of augmented α-adrenergic acute mental stress responses (diastolic BP, D-dimer and testosterone) were associated with circulating VWF levels in Africans (Adj R(2) 0.24; p<0.05). CONCLUSIONS An interdependence between acute mental stress, salivary testosterone, D-dimer and vascular responses existed in African males in their association with circulating VWF but no interdependence of the independent variables occurred with fibrinogen levels.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology > Centre of Competence for Psychosomatic Medicine

UniBE Contributor:

von Känel, Roland


600 Technology > 610 Medicine & health








Annette Barbara Kocher

Date Deposited:

13 Jun 2014 12:14

Last Modified:

26 Oct 2015 11:21

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Acute stress, D-dimer, Fibrinogen, Haemostasis, Testosterone, von Willebrand factor





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