Longitudinal Relationship of Low Leisure Satisfaction but not Depressive Symptoms With Systemic Low-Grade Inflammation in Dementia Caregivers.

von Känel, Roland; Mausbach, Brent T.; Mills, Paul J.; Dimsdale, Joel E.; Patterson, Thomas L.; Ancoli-Israel, Sonia; Ziegler, Michael G.; Allison, Matthew; Chattillion, Elizabeth A.; Grant, Igor (2014). Longitudinal Relationship of Low Leisure Satisfaction but not Depressive Symptoms With Systemic Low-Grade Inflammation in Dementia Caregivers. The journals of gerontology. Series B, Psychological sciences and social sciences, 69(3), pp. 397-407. Oxford University Press 10.1093/geronb/gbt020

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Objectives.This study aimed to further elucidate the biobehavioral mechanisms linking dementia caregiving with an increased cardiovascular disease risk. We hypothesized that both elevated depressive symptoms and a behavioral correlate of depression, low leisure satisfaction, are associated with systemic inflammation.Method.We studied 121 elderly Alzheimer's disease caregivers who underwent 4 annual assessments for depressive symptoms, leisure satisfaction, and circulating levels of inflammatory markers. We used mixed-regression analyses controlling for sociodemographic and health-relevant covariates to examine longitudinal relationships between constructs of interest. RESULTS: There were inverse relationships between total leisure satisfaction and tumor necrosis factor-α (TNF-α; p = .047), interleukin-8 (IL-8; p < .001), and interferon-γ (IFG; p = .020) but not with IL-6 (p = .21) and C-reactive protein (p = .65). Lower enjoyment from leisure activities was related to higher levels of TNF-α (p = .045), IL-8 (p < .001), and IFG (p = .002), whereas lower frequency of leisure activities was related only to higher IL-8 levels (p = .023). Depressive symptoms were not associated with any inflammatory marker (all p values > .17). Depressive symptoms did not mediate the relationship between leisure satisfaction and inflammation.Discussion.Lower satisfaction with leisure activities is related to higher low-grade systemic inflammation. This knowledge may provide a promising way of improving cardiovascular health in dementia caregivers through behavioral activation treatments targeting low leisure satisfaction.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology > Centre of Competence for Psychosomatic Medicine

UniBE Contributor:

von Känel, Roland

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1758-5368

Publisher:

Oxford University Press

Language:

English

Submitter:

Annette Barbara Kocher

Date Deposited:

14 Jul 2014 15:44

Last Modified:

27 Apr 2018 08:33

Publisher DOI:

10.1093/geronb/gbt020

PubMed ID:

23650246

Uncontrolled Keywords:

Biomarkers, Blood coagulation, Cardiovascular disease, Depression, Inflammation, Psychological stress

BORIS DOI:

10.7892/boris.47258

URI:

https://boris.unibe.ch/id/eprint/47258

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