Safety of non-therapeutic atomoxetine exposures - a national poison data system study

Monte, Andrew A; Ceschi, Alessandro; Bodmer, Michael (2013). Safety of non-therapeutic atomoxetine exposures - a national poison data system study. Human Psychopharmacology: Clinical and Experimental, 28(5), pp. 471-476. Wiley 10.1002/hup.2334

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AIMS This study's objective is to assess the safety of non-therapeutic atomoxetine exposures reported to the US National Poison Database System (NPDS). METHODS This is a retrospective database study of non-therapeutic single agent ingestions of atomoxetine in children and adults reported to the NPDS between 2002 and 2010. RESULTS A total of 20 032 atomoxetine exposures were reported during the study period, and 12 370 of these were single agent exposures. The median age was 9 years (interquartile range 3, 14), and 7380 were male (59.7%). Of the single agent exposures, 8813 (71.2%) were acute exposures, 3315 (26.8%) were acute-on-chronic, and 166 (1.3%) were chronic. In 10 608 (85.8%) cases, exposure was unintentional, in 1079 (8.7%) suicide attempts, and in 629 (5.1%) cases abuse. Of these cases, 3633 (29.4 %) were managed at health-care facilities. Acute-on-chronic exposure was associated with an increased risk of a suicidal reason for exposure compared with acute ingestions (odds ratio 1.44, 95% confidence interval 1.26-1.65). Most common clinical effects were drowsiness or lethargy (709 cases; 5.7%), tachycardia (555; 4.5%), and nausea (388; 3.1%). Major toxicity was observed in 21 cases (seizures in nine (42.9%), tachycardia in eight (38.1%), coma in six (28.6%), and ventricular dysrhythmia in one case (4.8%)). CONCLUSIONS Non-therapeutic atomoxetine exposures were largely safe, but seizures were rarely observed.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine > Centre of Competence for General Internal Medicine
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine

UniBE Contributor:

Bodmer, Michael

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1099-1077

Publisher:

Wiley

Language:

English

Submitter:

Patricia Rajaonina

Date Deposited:

28 Mar 2014 16:17

Last Modified:

15 Sep 2014 09:54

Publisher DOI:

10.1002/hup.2334

PubMed ID:

23861380

Uncontrolled Keywords:

Strattera, atomoxetine, drug safety, poisoning, seizure, suicidal intent

URI:

https://boris.unibe.ch/id/eprint/47401

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