Case-control analysis on metformin and cancer of the esophagus

Becker, Claudia; Meier, Christoph R.; Jick, Susan S.; Bodmer, Michael (2013). Case-control analysis on metformin and cancer of the esophagus. CCC. Cancer causes & control, 24(10), pp. 1763-1770. Springer Netherlands 10.1007/s10552-013-0253-6

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PURPOSE Metformin use has been associated with decreased cancer risks, though data on esophageal cancer are scarce. We explored the relation between use of metformin or other anti-diabetic drugs and the risk of esophageal cancer. METHODS We conducted a case-control analysis in the UK-based general practice research database (GPRD, now clinical practice research datalink, CPRD). Cases were individuals with an incident diagnosis of esophageal cancer between 1994 and 2010 at age 40-89 years. Ten controls per case were matched on age, sex, calendar time, general practice, and number of years of active history in the GPRD prior to the index date. Various potential confounders including diabetes mellitus, gastro-esophageal reflux, and use of proton-pump inhibitors were evaluated in univariate models, and the final results were adjusted for BMI and smoking. Results are presented as odds ratios (ORs) with 95 % confidence intervals (CI). RESULTS Long-term use (≥30 prescriptions) of metformin was not associated with a materially altered risk of esophageal cancer (adj. OR 1.23, 95 % CI 0.92-1.65), nor was long-term use of sulfonylureas (adj. OR 0.93, 95 % CI 0.70-1.23), insulin (adj. OR 0.87, 95 % CI 0.60-1.25), or of thiazolidinediones (adj. OR 0.71, 95 % CI 0.37-1.36). CONCLUSION In our population-based study, use of metformin was not associated with an altered risk of esophageal cancer.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine > Centre of Competence for General Internal Medicine
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine

UniBE Contributor:

Bodmer, Michael

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0957-5243

Publisher:

Springer Netherlands

Language:

English

Submitter:

Patricia Rajaonina

Date Deposited:

28 Mar 2014 15:34

Last Modified:

01 Oct 2018 02:31

Publisher DOI:

10.1007/s10552-013-0253-6

PubMed ID:

23820930

BORIS DOI:

10.7892/boris.47404

URI:

https://boris.unibe.ch/id/eprint/47404

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