Pharmacokinetics of meprobamate in overdose treated with continuous venovenous hemodiafiltration (CVVHDF)

Ceschi, Alessandro; Berger, David; Dickenmann, Michael; Bodmer, Michael (2013). Pharmacokinetics of meprobamate in overdose treated with continuous venovenous hemodiafiltration (CVVHDF). Hemodialysis International, 17(4), pp. 656-659. Wiley-Blackwell 10.1111/hdi.12047

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We report a case of massive suicidal overdose of meprobamate leading to cardiovascular collapse, respiratory failure, and severe central nervous system depression. We observed first-order elimination kinetics despite significant overdose, and demonstrated effectiveness of continuous venovenous hemodiafiltration (CVVHDF) for extracorporeal removal of meprobamate in this patient. Total body clearance was calculated to be 87 mL/minute, with 64 mL/minute (74%) due to CVVHDF. CVVHDF was stopped after 36 hours, and the patient made an uneventful recovery.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine > Centre of Competence for General Internal Medicine
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine

UniBE Contributor:

Berger, David and Bodmer, Michael

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1542-4758; 1492-7535

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Patricia Rajaonina

Date Deposited:

28 Mar 2014 15:38

Last Modified:

09 Nov 2015 10:55

Publisher DOI:

10.1111/hdi.12047

PubMed ID:

23615322

Uncontrolled Keywords:

CVVHDF, Poisoning, hemodiafiltration, meprobamate

URI:

https://boris.unibe.ch/id/eprint/47407

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