Metformin and the risk of endometrial cancer: a case-control analysis

Becker, Claudia; Jick, Susan S; Meier, Christoph R; Bodmer, Michael (2013). Metformin and the risk of endometrial cancer: a case-control analysis. Gynecologic oncology, 129(3), pp. 565-569. Elsevier 10.1016/j.ygyno.2013.03.009

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OBJECTIVE To explore the risk of endometrial cancer in relation to metformin and other antidiabetic drugs. METHODS We conducted a case-control analysis to explore the association between use of metformin and other antidiabetic drugs and the risk of endometrial cancer using the UK-based General Practice Research Database (GPRD). Cases were women with an incident diagnosis of endometrial cancer, and up to 6 controls per case were matched in age, sex, calendar time, general practice, and number of years of active history in the GPRD prior to the index date. Odds ratios (ORs) with 95% confidence intervals (95% CI) were calculated and results were adjusted by multivariate logistic regression analyses for BMI, smoking, a recorded diagnosis of diabetes mellitus, and diabetes duration. RESULTS A total of 2554 cases with incident endometrial cancer and 15,324 matched controls were identified. Ever use of metformin compared to never use of metformin was not associated with an altered risk of endometrial cancer (adj. OR 0.86, 95% CI 0.63-1.18). Stratified by exposure duration, neither long-term (≥25 prescriptions) use of metformin (adj. OR 0.79, 95% CI 0.54-1.17), nor long-term use of sulfonylureas (adj. OR 0.96, 95% CI 0.65-1.44), thiazolidinediones (≥15 prescriptions; adj. OR 1.22, 95% CI 0.67-2.21), or insulin (adj. OR 1.05 (0.79-1.82) was associated with the risk of endometrial cancer. CONCLUSION Use of metformin and other antidiabetic drugs were not associated with an altered risk of endometrial cancer.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine > Centre of Competence for General Internal Medicine
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine

UniBE Contributor:

Bodmer, Michael

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0090-8258

Publisher:

Elsevier

Language:

English

Submitter:

Patricia Rajaonina

Date Deposited:

31 Mar 2014 11:02

Last Modified:

15 Sep 2014 09:41

Publisher DOI:

10.1016/j.ygyno.2013.03.009

PubMed ID:

23523618

URI:

https://boris.unibe.ch/id/eprint/47411

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