Pica, Alessia; Abbeel, Sarah; Von der Weid, Nicolas; Sajadi, Ali; Negretti, Laura; Phan-Hug, Franziska; Haudenschild, Michael; Schmidhalter, Daniel; Schwitzgebel, Valerie; Weber, Damien (2013). Fractionated stereotactic radiotherapy with static field conformal and non coplanar arcs for pediatric patients with craniopharyngioma: analysis of long term visual outcome and endocrine toxicity. Journal of radiosurgery & SBRT, 2(3), pp. 209-216. Old City Publ.
Full text not available from this repository.We assessed the efficacy and the toxicity for pediatric craniopharyngioma patients of fractionated stereotactic radiotherapy (FSRT). Between May 2000 and May 2009, 9 patients (male to female ratio, 5:4) with craniopharyngiomas underwent FSRT (median dose, 54 Gy). Among the 9 patients, 6 received radiation therapy (RT) for recurrent tumors and 3 for residual disease as adjuvant therapy after incomplete surgery. Median tumor 3 volume was 2.3 cm (range, 0.1-5.8). The median target coverage was 93.7% (range 79.3-99.8%). The median conformity index was 0.94 (range, 0.6-1.4). Dose to the hippocampal region was assessed for all patients. After a median follow-up of 62.5 months (range, 32-127)the treated volume decreased in size in four of eight patients (50%). One patient was lost to follow-up. Local control and survival rates at 3 years were 100% and there were no marginal relapses. One patient, with a chronic bilateral papillary oedema after surgery, visual defect deteriorated after FSRT to a complete hemianopsia. One male patient with normal pituitary function before FSRT presented with precocious puberty at the age of 7.4 years, 24 months after FSRT. Four patients (50%) were severely obese at their last visit. FSRT is a safe treatment option for craniopharyngioma after incomplete resection.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology 04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology > Medical Radiation Physics 04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology |
UniBE Contributor: |
Pica, Alessia, Abbeel, Sarah, Von der Weid, Nicolas, Schmidhalter, Daniel, Weber, Damien Charles |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2156-4639 |
Publisher: |
Old City Publ. |
Language: |
English |
Submitter: |
Beatrice Scheidegger |
Date Deposited: |
24 Apr 2014 09:19 |
Last Modified: |
05 Dec 2022 14:32 |
URI: |
https://boris.unibe.ch/id/eprint/47825 |
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