The Cytotoxic Mode of Action of the Venom of Cupiennius salei (Ctenidae)

Nentwig, Wolfgang; Kuhn-Nentwig, Lucia Gerda (2013). The Cytotoxic Mode of Action of the Venom of Cupiennius salei (Ctenidae). In: Nentwig, Wolfgang (ed.) Spider Ecophysiology (pp. 217-228). Berlin: Springer 10.1007/978-3-642-33989-9_16

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The venom of the ctenid spider Cupiennius salei (Fig.16.1) is rich in components which belong to different functional groups. Besides low molecular mass compounds, the venom contains several disulphide-rich peptides, also called mini-proteins, which act as neurotoxins on ion channels or as enhancers of neurotoxins. Likewise, a variety of small cytolytic peptides, which destroy membranes very efficiently, and enzymes are present in the venom. Neurotoxins with cytolytic activity, cytolytic a-helical small cationic peptides and enzymes most probably attacking connective tissue and phospholipid membranes cause the overall cytotoxic effect of this venom. Synergistic and enhancing interactions between components enable the spider to achieve a maximum of toxicity with a minimum of venom quantity.

Item Type:

Book Section (Book Chapter)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Ecology and Evolution (IEE)
08 Faculty of Science > Department of Biology > Institute of Ecology and Evolution (IEE) > Community Ecology

UniBE Contributor:

Nentwig, Wolfgang and Kuhn-Nentwig, Lucia Gerda

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 590 Animals (Zoology)
500 Science > 580 Plants (Botany)

ISBN:

978-3-642-33988-2

Publisher:

Springer

Language:

English

Submitter:

Alexander Strauss

Date Deposited:

04 Aug 2014 11:59

Last Modified:

04 Dec 2014 22:55

Publisher DOI:

10.1007/978-3-642-33989-9_16

BORIS DOI:

10.7892/boris.47991

URI:

https://boris.unibe.ch/id/eprint/47991

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