Tarnanas, Ioannis; Tsolaki, Magda; Nef, Tobias; Müri, René Martin; Mosimann, Urs Peter (2014). Can a novel computerized cognitive screening test provide additional information for early detection of Alzheimer's disease? Alzheimer's & dementia, 10(6), pp. 790-798. Elsevier 10.1016/j.jalz.2014.01.002
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BACKGROUND:
Virtual reality testing of everyday activities is a novel type of computerized assessment that measures cognitive, executive, and motor performance as a screening tool for early dementia. This study used a virtual reality day-out task (VR-DOT) environment to evaluate its predictive value in patients with mild cognitive impairment (MCI).
METHODS:
One hundred thirty-four patients with MCI were selected and compared with 75 healthy control subjects. Participants received an initial assessment that included VR-DOT, a neuropsychological evaluation, magnetic resonance imaging (MRI) scan, and event-related potentials (ERPs). After 12 months, participants were assessed again with MRI, ERP, VR-DOT, and neuropsychological tests.
RESULTS:
At the end of the study, we differentiated two subgroups of patients with MCI according to their clinical evolution from baseline to follow-up: 56 MCI progressors and 78 MCI nonprogressors. VR-DOT performance profiles correlated strongly with existing predictive biomarkers, especially the ERP and MRI biomarkers of cortical thickness.
CONCLUSIONS:
Compared with ERP, MRI, or neuropsychological tests alone, the VR-DOT could provide additional predictive information in a low-cost, computerized, and noninvasive way.
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