Can a novel computerized cognitive screening test provide additional information for early detection of Alzheimer's disease?

Tarnanas, Ioannis; Tsolaki, Magda; Nef, Tobias; Müri, René Martin; Mosimann, Urs Peter (2014). Can a novel computerized cognitive screening test provide additional information for early detection of Alzheimer's disease? Alzheimer's & dementia, 10(6), pp. 790-798. Elsevier 10.1016/j.jalz.2014.01.002

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BACKGROUND: Virtual reality testing of everyday activities is a novel type of computerized assessment that measures cognitive, executive, and motor performance as a screening tool for early dementia. This study used a virtual reality day-out task (VR-DOT) environment to evaluate its predictive value in patients with mild cognitive impairment (MCI). METHODS: One hundred thirty-four patients with MCI were selected and compared with 75 healthy control subjects. Participants received an initial assessment that included VR-DOT, a neuropsychological evaluation, magnetic resonance imaging (MRI) scan, and event-related potentials (ERPs). After 12 months, participants were assessed again with MRI, ERP, VR-DOT, and neuropsychological tests. RESULTS: At the end of the study, we differentiated two subgroups of patients with MCI according to their clinical evolution from baseline to follow-up: 56 MCI progressors and 78 MCI nonprogressors. VR-DOT performance profiles correlated strongly with existing predictive biomarkers, especially the ERP and MRI biomarkers of cortical thickness. CONCLUSIONS: Compared with ERP, MRI, or neuropsychological tests alone, the VR-DOT could provide additional predictive information in a low-cost, computerized, and noninvasive way.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Geriatric Psychiatry and Psychotherapy
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Gerontechnology and Rehabilitation
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Pavillon 52 > Forschungsgruppe Perzeption und Okulomotorik

UniBE Contributor:

Tarnanas, Ioannis; Nef, Tobias; Müri, René Martin and Mosimann, Urs Peter

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1552-5279

Publisher:

Elsevier

Language:

English

Submitter:

Vanessa Vallejo

Date Deposited:

04 Jul 2014 09:01

Last Modified:

31 Jan 2019 11:05

Publisher DOI:

10.1016/j.jalz.2014.01.002

PubMed ID:

24656838

Uncontrolled Keywords:

Computerized cognitive assessment, Computerized testing, Dementia, Early detection, Psychometrics

BORIS DOI:

10.7892/boris.48017

URI:

https://boris.unibe.ch/id/eprint/48017

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