Physiologic and hematologic concerns of rotary blood pumps: what needs to be improved?

Pirbodaghi, Tohid; Asgari, Siavash; Cotter, Chris; Bourque, Kevin (2014). Physiologic and hematologic concerns of rotary blood pumps: what needs to be improved? Heart Failure Reviews, 19(2), pp. 259-266. Springer 10.1007/s10741-013-9389-4

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Over the past few decades, advances in ventricular assist device (VAD) technology have provided a promising therapeutic strategy to treat heart failure patients. Despite the improved performance and encouraging clinical outcomes of the new generation of VADs based on rotary blood pumps (RBPs), their physiologic and hematologic effects are controversial. Currently, clinically available RBPs run at constant speed, which results in limited control over cardiac workload and introduces blood flow with reduced pulsatility into the circulation. In this review, we first provide an update on the new challenges of mechanical circulatory support using rotary pumps including blood trauma, increased non-surgical bleeding rate, limited cardiac unloading, vascular malformations, end-organ function, and aortic valve insufficiency. Since the non-physiologic flow characteristic of these devices is one of the main subjects of scientific debate in the literature, we next emphasize the latest research regarding the development of a pulsatile RBP. Finally, we offer an outlook for future research in the field.

Item Type:

Journal Article (Original Article)

Division/Institute:

10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Cardiovascular Engineering (CVE)

UniBE Contributor:

Pirbodaghi, Tohid

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1382-4147

Publisher:

Springer

Language:

English

Submitter:

Francesco Clavica

Date Deposited:

10 Apr 2014 00:27

Last Modified:

02 Nov 2015 09:51

Publisher DOI:

10.1007/s10741-013-9389-4

PubMed ID:

23549998

BORIS DOI:

10.7892/boris.48024

URI:

https://boris.unibe.ch/id/eprint/48024

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