Neuroimaging of epilepsy: lesions, networks, oscillations

Abela, Eugenio; Rummel, Christian; Hauf, Martinus; Weisstanner, Christian; Schindler, Kaspar Anton; Wiest, Roland (2014). Neuroimaging of epilepsy: lesions, networks, oscillations. Clinical neuroradiology, 24(1), pp. 5-15. Springer 10.1007/s00062-014-0284-8

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While analysis and interpretation of structural epileptogenic lesion is an essential task for the neuroradiologist in clinical practice, a substantial body of epilepsy research has shown that focal lesions influence brain areas beyond the epileptogenic lesion, across ensembles of functionally and anatomically connected brain areas. In this review article, we aim to provide an overview about altered network compositions in epilepsy, as measured with current advanced neuroimaging techniques to characterize the initiation and spread of epileptic activity in the brain with multimodal noninvasive imaging techniques. We focus on resting-state functional magnetic resonance imaging (MRI) and simultaneous electroencephalography/fMRI, and oppose the findings in idiopathic generalized versus focal epilepsies. These data indicate that circumscribed epileptogenic lesions can have extended effects on many brain systems. Although epileptic seizures may involve various brain areas, seizure activity does not spread diffusely throughout the brain but propagates along specific anatomic pathways that characterize the underlying epilepsy syndrome. Such a functionally oriented approach may help to better understand a range of clinical phenomena such as the type of cognitive impairment, the development of pharmacoresistance, the propagation pathways of seizures, or the success of epilepsy surgery.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Abela, Eugenio; Rummel, Christian; Hauf, Martinus; Weisstanner, Christian; Schindler, Kaspar Anton and Wiest, Roland

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1869-1439

Publisher:

Springer

Language:

English

Submitter:

Martin Zbinden

Date Deposited:

06 Oct 2014 16:39

Last Modified:

29 Oct 2015 11:43

Publisher DOI:

10.1007/s00062-014-0284-8

PubMed ID:

24424576

Uncontrolled Keywords:

Epilepsy, Networks, Functional neuroimaging

BORIS DOI:

10.7892/boris.48078

URI:

https://boris.unibe.ch/id/eprint/48078

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