Left posterior parietal theta burst stimulation affects gestural imitation regardless of semantic content.

Vanbellingen, Tim; Bertschi, Manuel; Nyffeler, Thomas; Cazzoli, Dario; Wiest, Roland; Bassetti, Claudio; Kaelin-Lang, Alain; Müri, René; Bohlhalter, Stephan (2014). Left posterior parietal theta burst stimulation affects gestural imitation regardless of semantic content. Clinical neurophysiology, 125(3), pp. 457-462. Elsevier 10.1016/j.clinph.2013.07.024

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OBJECTIVE Neuro-imaging studies have suggested that the ability to imitate meaningless and meaningful gestures may differentially depend on superior (SPL) and inferior (IPL) parietal lobule. Therefore, we hypothesized that imaging-guided neuro-navigated continuous theta burst stimulation (cTBS) over left SPL mainly affects meaningless and over left IPL predominantly meaningful gestures. METHODS Twelve healthy subjects participated in this study. High resolution structural MRI was used for imaging guided neuro-navigation cTBS. Participants were targeted with one train of cTBS in three experimental sessions: sham stimulation over vertex and real cTBS over left SPL and IPL, respectively. An imitation task, including 24 meaningless and 24 meaningful gestures, was performed 'offline'. RESULTS cTBS over both left IPL and SPL significantly interfered with gestural imitation. There was no differential effect of SPL and IPL cTBS on gesture type (meaningless versus meaningful). CONCLUSIONS Our findings confirm that left posterior parietal cortex plays a predominant role in gestural imitation. However, the hypothesis based on the dual route model suggesting a differential role of SPL and IPL in the processing of meaningless and meaningful gestures could not be confirmed. SIGNIFICANCE Left SPL and IPL play a common role within the posterior-parietal network in gestural imitation regardless of semantic content.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

UniBE Contributor:

Vanbellingen, Tim; Bertschi, Manuel; Nyffeler, Thomas; Cazzoli, Dario; Wiest, Roland; Bassetti, Claudio; Kaelin, Alain; Müri, René Martin and Bohlhalter, Stephan

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1388-2457

Publisher:

Elsevier

Language:

English

Submitter:

Martin Zbinden

Date Deposited:

12 Jun 2014 08:14

Last Modified:

29 Oct 2015 11:43

Publisher DOI:

10.1016/j.clinph.2013.07.024

PubMed ID:

24054467

Uncontrolled Keywords:

Gestures, IPL, Imitation, SPL, Theta burst stimulation

BORIS DOI:

10.7892/boris.48084

URI:

https://boris.unibe.ch/id/eprint/48084

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