Age-related normal structural and functional ventricular values in cardiac function assessed by magnetic resonance

Fiechter, Michael; Fuchs, Tobias A.; Gebhard, Catherine; Stehli, Julia; Klaeser, Bernd; Stähli, Barbara E.; Manka, Robert; Manes, Costantina; Tanner, Felix C.; Gaemperli, Oliver; Kaufmann, Philipp A. (2013). Age-related normal structural and functional ventricular values in cardiac function assessed by magnetic resonance. BMC medical imaging, 13, p. 6. BioMed Central 10.1186/1471-2342-13-6

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BACKGROUND The heart is subject to structural and functional changes with advancing age. However, the magnitude of cardiac age-dependent transformation has not been conclusively elucidated. METHODS This retrospective cardiac magnetic resonance (CMR) study included 183 subjects with normal structural and functional ventricular values. End systolic volume (ESV), end diastolic volume (EDV), and ejection fraction (EF) were obtained from the left and the right ventricle in breath-hold cine CMR. Patients were classified into four age groups (20-29, 30-49, 50-69, and ≥70 years) and cardiac measurements were compared using Pearson's rank correlation over the four different groups. RESULTS With advanced age a slight but significant decrease in ESV (r=-0.41 for both ventricles, P<0.001) and EDV (r=-0.39 for left ventricle, r=-0.35 for right ventricle, P<0.001) were observed associated with a significant increase in left (r=0.28, P<0.001) and right (r=0.27, P<0.01) ventricular EF reaching a maximal increase in EF of +8.4% (P<0.001) for the left and +6.1% (P<0.01) for the right ventricle in the oldest compared to the youngest patient group. Left ventricular myocardial mass significantly decreased over the four different age groups (P<0.05). CONCLUSIONS The aging process is associated with significant changes in left and right ventricular EF, ESV and EDV in subjects with no cardiac functional and structural abnormalities. These findings underline the importance of using age adapted values as standard of reference when evaluating CMR studies.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine

UniBE Contributor:

Klaeser, Bernd


600 Technology > 610 Medicine & health




BioMed Central




Franziska Nicoletti

Date Deposited:

25 Jun 2014 16:49

Last Modified:

20 Mar 2018 13:24

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

CMR, Age, LV-EF, RV-EF, Normal values




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