[New oral anticoagulants - influence on coagulation tests].

Simeon, L; Nagler, Michael; Wuillemin, Walter Alfred (2014). [New oral anticoagulants - influence on coagulation tests]. Deutsche medizinische Wochenschrift, 139(3), pp. 94-99. Thieme 10.1055/s-0033-1359920

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The new oral anticoagulants (NOACs) represent alternative antithrombotic agents for prophylaxis and therapy of thromboembolic diseases. They act either by inhibition of the clotting factor Xa or IIa (thrombin). As a consequence, they influence several coagulation assays (for example prothrombin time, activated partial thromboplastin time). Because of the short half-life of these new agents, these changes show great variations in the course of 24 hours. Furthermore, there are significant differences of laboratory results depending on the used reagents. We explain the influence of apixaban, rivaroxaban (factor Xa inhibitors) and dabigatran (thrombin inhibitor) on the most commonly used coagulation assays. Besides we show that this influence depends on the way of action of the drug as well as on the principle of the coagulation assay. Being aware of this relationships helps to interpret the results of coagulation assays under influence of NOACs correctly.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Other Institutions > Teaching Staff, Faculty of Medicine
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory

UniBE Contributor:

Nagler, Michael and Wuillemin, Walter Alfred

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0012-0472

Publisher:

Thieme

Language:

English

Submitter:

Verena Zwahlen

Date Deposited:

30 Sep 2014 13:59

Last Modified:

10 Sep 2017 16:20

Publisher DOI:

10.1055/s-0033-1359920

PubMed ID:

24399657

BORIS DOI:

10.7892/boris.48374

URI:

https://boris.unibe.ch/id/eprint/48374

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