Significance of coagulopathy in recurrent abortions

Demarmels Biasiutti, Franziska (2013). Significance of coagulopathy in recurrent abortions. Gynäkologische Endokrinologie, 11(2), pp. 95-99. Springer-Verlag 10.1007/s10304-012-0519-1

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Habitual abortions Spontaneous abortion occurs in about 15 % of all clinically diagnosed pregnancies. It is a very traumatic experience for the concerned couple longing for a child. This is especially true in case of recurrent abortions (≥ 3 successive abortions), which occur in about 1 % of all pregnancies. With the hope of avoiding further abortions, extensive efforts are made to determine the cause. Physiological coagulatory influences In addition to various possible organic etiologies of abortion and cytogenetic abnormalities of the fetus, disorders of hemostasis and thrombosis of the mother, especially prothrombotic disorders (thrombophilias) play possible pathophysiological roles. During pregnancy, these can be associated with abnormally high levels of prothrombin, which can potentially limit the blood supply to the fetus, thus increasing the risk of abortion. Thrombophilia If the physiological procoagulatory effect of pregnancy due to upregulation of various prothrombotic coagulation factors and at the same time downregulation of anticoagulatory proteins coincides with a possible hereditary thrombophilia of the pregnant woman, the thrombotic risk is further elevated and represents a risk not only for the mother but also possibly for the child in case of placental thrombosis. Therefore, women with a thrombophilic defect need an antithrombotic prophylaxis not only for the prevention of thrombosis but possibly as well for the prevention of abortion.

Item Type:

Journal Article (Review Article)


04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory

UniBE Contributor:

Demarmels Biasiutti, Franziska


600 Technology > 610 Medicine & health








Verena Zwahlen

Date Deposited:

13 Jun 2014 12:29

Last Modified:

23 Oct 2019 08:56

Publisher DOI:





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