Less structured movement patterns predict severity of positive syndrome, excitement, and disorganization

Walther, Sebastian; Ramseyer, Fabian; Horn, Helge; Strik, Werner; Tschacher, Wolfgang (2014). Less structured movement patterns predict severity of positive syndrome, excitement, and disorganization. Schizophrenia bulletin, 40(3), pp. 585-591. Oxford University Press 10.1093/schbul/sbt038

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Disorganized behavior is a key symptom of schizophrenia. The objective assessment of disorganized behavior is particularly challenging. Actigraphy has enabled the objective assessment of motor behavior in various settings. Reduced motor activity was associated with negative syndrome scores, but simple motor activity analyses were not informative on other symptom dimensions. The analysis of movement patterns, however, could be more informative for assessing schizophrenia symptom dimensions. Here, we use time series analyses on actigraphic data of 100 schizophrenia spectrum disorder patients. Actigraphy recording intervals were set at 2 s. Data from 2 defined 60-min periods were analyzed, and partial autocorrelations of the actigraphy time series indicated predictability of movements in each individual. Increased positive syndrome scores were associated with reduced predictability of movements but not with the overall amount of movement. Negative syndrome scores were associated with low activity levels but unrelated with predictability of movement. The factors disorganization and excitement were related to movement predictability but emotional distress was not. Thus, the predictability of objectively assessed motor behavior may be a marker of positive symptoms and disorganized behavior. This behavior could become relevant for translational research.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychotherapy
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Management
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > UPD Murtenstrasse

UniBE Contributor:

Walther, Sebastian; Ramseyer, Fabian; Horn, Helge Joachim; Strik, Werner and Tschacher, Wolfgang

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0586-7614

Publisher:

Oxford University Press

Language:

English

Submitter:

Daniela Zurkinden

Date Deposited:

10 Apr 2014 10:51

Last Modified:

09 Nov 2015 11:47

Publisher DOI:

10.1093/schbul/sbt038

PubMed ID:

23502433

Uncontrolled Keywords:

schizophrenia, actigraphy, behavior, time series Analysis, positive symptoms, negative symptoms negative symptoms

BORIS DOI:

10.7892/boris.48415

URI:

https://boris.unibe.ch/id/eprint/48415

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