Chai, Qian; Onder, Lucas; Scandella, Elke; Gil-Cruz, Cristina; Perez-Shibayama, Christian; Cupovic, Jovana; Danuser, Renzo; Sparwasser, Tim; Luther, Sanjiv A.; Thiel, Volker; Rülicke, Thomas; Stein, Jens Volker; Hehlgans, Thomas; Ludewig, Burkhard (2013). Maturation of lymph node fibroblastic reticular cells from myofibroblastic precursors is critical for antiviral immunity. Immunity, 38(5), pp. 1013-1024. Cell Press 10.1016/j.immuni.2013.03.012
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The stromal scaffold of the lymph node (LN) paracortex is built by fibroblastic reticular cells (FRCs). Conditional ablation of lymphotoxin-β receptor (LTβR) expression in LN FRCs and their mesenchymal progenitors in developing LNs revealed that LTβR-signaling in these cells was not essential for the formation of LNs. Although T cell zone reticular cells had lost podoplanin expression, they still formed a functional conduit system and showed enhanced expression of myofibroblastic markers. However, essential immune functions of FRCs, including homeostatic chemokine and interleukin-7 expression, were impaired. These changes in T cell zone reticular cell function were associated with increased susceptibility to viral infection. Thus, myofibroblasic FRC precursors are able to generate the basic T cell zone infrastructure, whereas LTβR-dependent maturation of FRCs guarantees full immunocompetence and hence optimal LN function during infection.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute |
UniBE Contributor: |
Danuser, Renzo, Stein, Jens Volker |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1074-7613 |
Publisher: |
Cell Press |
Language: |
English |
Submitter: |
Ursula Zingg-Zünd |
Date Deposited: |
13 Jun 2014 16:11 |
Last Modified: |
05 Dec 2022 14:32 |
Publisher DOI: |
10.1016/j.immuni.2013.03.012 |
PubMed ID: |
23623380 |
BORIS DOI: |
10.7892/boris.48603 |
URI: |
https://boris.unibe.ch/id/eprint/48603 |
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