Fixed low-dose ultrasound-assisted catheter-directed thrombolysis for intermediate- and high-risk pulmonary embolism

Engelberger, Rolf Peter; Moschovitis, Aris; Fahrni, Jennifer; Willenberg, Torsten Andreas; Baumann, Frederic; Diehm, Nicolas Alexander; Do, Dai-Do; Baumgartner, Iris; Kucher, Nils (2015). Fixed low-dose ultrasound-assisted catheter-directed thrombolysis for intermediate- and high-risk pulmonary embolism. European Heart Journal, 36(10), pp. 597-604. Oxford University Press 10.1093/eurheartj/eht531

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AIMS No standardized local thrombolysis regimen exists for the treatment of pulmonary embolism (PE). We retrospectively investigated efficacy and safety of fixed low-dose ultrasound-assisted catheter-directed thrombolysis (USAT) for intermediate- and high-risk PE. METHODS AND RESULTS Fifty-two patients (65 ± 14 years) of whom 14 had high-risk PE (troponin positive in all) and 38 intermediate-risk PE (troponin positive in 91%) were treated with intravenous unfractionated heparin and USAT using 10 mg of recombinant tissue plasminogen activator per device over the course of 15 h. Bilateral USAT was performed in 83% of patients. During 3-month follow-up, two [3.8%; 95% confidence interval (CI) 0.5-13%] patients died (one from cardiogenic shock and one from recurrent PE). Major non-fatal bleeding occurred in two (3.8%; 95% CI, 0.5-13%) patients: one intrathoracic bleeding after cardiopulmonary resuscitation requiring transfusion, one intrapulmonary bleeding requiring lobectomy. Mean pulmonary artery pressure decreased from 37 ± 9 mmHg at baseline to 25 ± 8 mmHg at 15 h (P < 0.001) and cardiac index increased from 2.0 ± 0.7 to 2.7 ± 0.9 L/min/m(2) (P < 0.001). Echocardiographic right-to-left ventricular end-diastolic dimension ratio decreased from 1.42 ± 0.21 at baseline to 1.06 ± 0.23 at 24 h (n = 21; P < 0.001). The greatest haemodynamic benefit from USAT was found in patients with high-risk PE and in those with symptom duration < 14 days. CONCLUSION A standardized catheter intervention approach using fixed low-dose USAT for the treatment of intermediate- and high-risk PE was associated with rapid improvement in haemodynamic parameters and low rates of bleeding complications and mortality.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Angiology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Angiologie
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Engelberger, Rolf Peter; Moschovitis, Aris; Fahrni, Jennifer; Willenberg, Torsten Andreas; Baumann, Frederic; Diehm, Nicolas Alexander; Do, Dai-Do; Baumgartner, Iris and Kucher, Nils

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0195-668X

Publisher:

Oxford University Press

Language:

English

Submitter:

Aris Moschovitis

Date Deposited:

11 Apr 2014 10:57

Last Modified:

28 Apr 2018 02:32

Publisher DOI:

10.1093/eurheartj/eht531

PubMed ID:

24334719

Uncontrolled Keywords:

Bleeding, Cardiac output, Catheter-directed thrombolysis, Mortality, Pulmonary artery pressure, Pulmonary embolism

BORIS DOI:

10.7892/boris.48870

URI:

https://boris.unibe.ch/id/eprint/48870

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