Micro- and nanostructured polymer substrates for biomedical applications

Althaus, Jasmin; Urwyler, Prabitha; Padeste, Celestino; Heuberger, Roman; Deyhle, Hans; Schift, Helmut; Gobrecht, Jens; Pieles, Uwe; Scharnweber, Dieter; Peters, Kirsten; Mueller, Bert (2012). Micro- and nanostructured polymer substrates for biomedical applications. Proceedings of SPIE - International Society for Optical Engineering, 8339, 83390Q. SPIE 10.1117/12.915235

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Polymer implants are interesting alternatives to the contemporary load-bearing implants made from metals. Polyetheretherketone (PEEK), a well-established biomaterial for example, is not only iso-elastic to bone but also permits investigating the surrounding soft tissues using magnetic resonance imaging or computed tomography, which is particularly important for cancer patients. The commercially available PEEK bone implants, however, require costly coatings, which restricts their usage. As an alternative to coatings, plasma activation can be applied. The present paper shows the plasma-induced preparation of nanostructures on polymer films and on injection-molded micro-cantilever arrays and the associated chemical modifications of the surface. In vitro cell experiments indicate the suitability of the activation process. In addition, we show that microstructures such as micro-grooves 1 μm deep and 20 μm wide cause cell alignment. The combination of micro-injection molding, simultaneous microstructuring using inserts/bioreplica and plasma treatments permits the preparation of polymer implants with nature-analogue, anisotropic micro- and nanostructures.

Item Type:	Journal Article (Original Article)
Division/Institute:	10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Gerontechnology and Rehabilitation
UniBE Contributor:	Urwyler-Harischandra, Prabitha
Subjects:	500 Science > 530 Physics 500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health 600 Technology > 620 Engineering
ISSN:	0277-786X
Publisher:	SPIE
Language:	English
Submitter:	Prabitha Urwyler-Harischandra
Date Deposited:	27 Jun 2014 09:50
Last Modified:	05 Dec 2022 14:32
Publisher DOI:	10.1117/12.915235
Uncontrolled Keywords:	Injection molding, embossing, PEEK film, plasma treatment, anisotropy, zeta-potential, XPS, mesenchymal stem cells
URI:	https://boris.unibe.ch/id/eprint/48975