Micro- and nanostructured polymer substrates for biomedical applications

Althaus, Jasmin; Urwyler, Prabitha; Padeste, Celestino; Heuberger, Roman; Deyhle, Hans; Schift, Helmut; Gobrecht, Jens; Pieles, Uwe; Scharnweber, Dieter; Peters, Kirsten; Mueller, Bert (2012). Micro- and nanostructured polymer substrates for biomedical applications. Proceedings of SPIE - International Society for Optical Engineering, 8339, 83390Q. SPIE 10.1117/12.915235

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Polymer implants are interesting alternatives to the contemporary load-bearing implants made from metals. Polyetheretherketone (PEEK), a well-established biomaterial for example, is not only iso-elastic to bone but also permits investigating the surrounding soft tissues using magnetic resonance imaging or computed tomography, which is particularly important for cancer patients. The commercially available PEEK bone implants, however, require costly coatings, which restricts their usage. As an alternative to coatings, plasma activation can be applied. The present paper shows the plasma-induced preparation of nanostructures on polymer films and on injection-molded micro-cantilever arrays and the associated chemical modifications of the surface. In vitro cell experiments indicate the suitability of the activation process. In addition, we show that microstructures such as micro-grooves 1 μm deep and 20 μm wide cause cell alignment. The combination of micro-injection molding, simultaneous microstructuring using inserts/bioreplica and plasma treatments permits the preparation of polymer implants with nature-analogue, anisotropic micro- and nanostructures.

Item Type:

Journal Article (Original Article)

Division/Institute:

10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Gerontechnology and Rehabilitation

UniBE Contributor:

Urwyler-Harischandra, Prabitha

Subjects:

500 Science > 530 Physics
500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health
600 Technology > 620 Engineering

ISSN:

0277-786X

Publisher:

SPIE

Language:

English

Submitter:

Prabitha Urwyler-Harischandra

Date Deposited:

27 Jun 2014 09:50

Last Modified:

08 Feb 2017 13:38

Publisher DOI:

10.1117/12.915235

Uncontrolled Keywords:

Injection molding, embossing, PEEK film, plasma treatment, anisotropy, zeta-potential, XPS, mesenchymal stem cells

URI:

https://boris.unibe.ch/id/eprint/48975

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