Swiss warmblood horse with symptoms of hereditary equine regional dermal asthenia without mutation in the cyclophylin B gene (PPIB)

Rüfenacht, Silvia; Straub, Reto; Steinmann, B.; Winand, N.; Bidaut, A.; Stoffel, Michael Hubert; Gerber, Vinzenz; Wyder, Marianne; Müller, Eliane; Roosje, Petra (2010). Swiss warmblood horse with symptoms of hereditary equine regional dermal asthenia without mutation in the cyclophylin B gene (PPIB). Schweizer Archiv für Tierheilkunde, 152(4), pp. 188-92. Bern: Huber 10.1024/0036-7281/a000042

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Hereditary equine dermal asthenia (HERDA) is an autosomal recessive skin disease that affects predominantly Quarter Horses and related breeds. Typical symptoms are easy bruising and hyperextensible skin on the back. The prognosis is guarded, as affected horses cannot be ridden normally and are often euthanised. In the Quarter Horse, HERDA is associated with a mutation in cyclophilin B (PPIB), an enzyme involved in triple helix formation of collagen. Here we describe the case of a Swiss Warmblood filly with symptoms of HERDA without PPIB-mutation and in which we also could exclude Ehlers-Danlos syndrome Type IV, VI, VIIA, VIIB and VIIC (dermatosparaxis type) as etiological diseases.

Item Type:	Journal Article (Original Article)
Division/Institute:	05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology 05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Veterinary Anatomy 05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Dermatology 05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > ISME Equine Clinic Bern > ISME Equine Clinic, Internal medicine
UniBE Contributor:	Rüfenacht, Silvia, Straub, Reto, Stoffel, Michael Hubert, Gerber, Vinzenz, Wyder, Marianne, Müller, Eliane Jasmine, Roosje Hasler, Pieternella
Subjects:	600 Technology > 630 Agriculture 500 Science > 570 Life sciences; biology
ISSN:	0036-7281
Publisher:	Huber
Language:	Multilingual
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:17
Last Modified:	02 Mar 2023 23:20
Publisher DOI:	10.1024/0036-7281/a000042
URI:	https://boris.unibe.ch/id/eprint/4982 (FactScience: 209647)