In Vitro Testing of a Temporary Catheter-Based Aortic "Parachute" Valve

Vandenberghe, Stijn; Salizzoni, Stefano; Bajona, Pietro; Zehr, Kenton J; Speziali, Giovanni (2008). In Vitro Testing of a Temporary Catheter-Based Aortic "Parachute" Valve. ASAIO journal, 54(6), pp. 574-577. Lippincott 10.1097/MAT.0b013e31818b3d93

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Recently developed technologies allow aortic valve implantation off-pump in a beating heart. In this procedure, the native, stenotic aortic valve is not removed, but simply crushed by a pressure balloon mounted on a percutaneous catheter. Removal of the native aortic cusps before valve replacement may reduce the incidence of annular or cuspal calcium embolization and late perivalvular leaks and increase implantable valve size. However, a temporary valve system in the ascending aorta may be necessary to maintain hemodynamic stability by reducing acute aortic regurgitation and left ventricular volume overload. This study evaluates the hemodynamic effects of a wire-mounted, monoleaflet, temporary valve apparatus in a mechanical cardiovascular simulator. Aortic flow, systemic pressure and left ventricular pressure were continuously monitored. An intraluminal camera obtained real-time proximal and distal images of the valve in operation. Insertion of the parachute valve in the simulator increased diastolic pressure from 7 to 38 mm Hg. Cardiac output increased from 2.08 to 4.66 L/min and regurgitant volume decreased from 65 to 23 mL. In conclusion, placement of a temporary valve in the ascending aorta may help maintain hemodynamic stability and improve off-pump aortic valve replacement.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Heart Surgery
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Cardiovascular Engineering (CVE)

UniBE Contributor:

Vandenberghe, Stijn


600 Technology > 610 Medicine & health








Francesco Clavica

Date Deposited:

10 Apr 2014 01:21

Last Modified:

27 Feb 2024 14:29

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Aortic Valve, Heart Valve Prosthesis, Hemodynamics, Prosthesis Design




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