In Vitro Testing of a Temporary Catheter-Based Aortic "Parachute" Valve

Vandenberghe, Stijn; Salizzoni, Stefano; Bajona, Pietro; Zehr, Kenton J; Speziali, Giovanni (2008). In Vitro Testing of a Temporary Catheter-Based Aortic "Parachute" Valve. ASAIO journal, 54(6), pp. 574-577. Lippincott 10.1097/MAT.0b013e31818b3d93

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Recently developed technologies allow aortic valve implantation off-pump in a beating heart. In this procedure, the native, stenotic aortic valve is not removed, but simply crushed by a pressure balloon mounted on a percutaneous catheter. Removal of the native aortic cusps before valve replacement may reduce the incidence of annular or cuspal calcium embolization and late perivalvular leaks and increase implantable valve size. However, a temporary valve system in the ascending aorta may be necessary to maintain hemodynamic stability by reducing acute aortic regurgitation and left ventricular volume overload. This study evaluates the hemodynamic effects of a wire-mounted, monoleaflet, temporary valve apparatus in a mechanical cardiovascular simulator. Aortic flow, systemic pressure and left ventricular pressure were continuously monitored. An intraluminal camera obtained real-time proximal and distal images of the valve in operation. Insertion of the parachute valve in the simulator increased diastolic pressure from 7 to 38 mm Hg. Cardiac output increased from 2.08 to 4.66 L/min and regurgitant volume decreased from 65 to 23 mL. In conclusion, placement of a temporary valve in the ascending aorta may help maintain hemodynamic stability and improve off-pump aortic valve replacement.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiovascular Surgery
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Cardiovascular Engineering (CVE)

UniBE Contributor:

Vandenberghe, Stijn

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1058-2916

Publisher:

Lippincott

Language:

English

Submitter:

Francesco Clavica

Date Deposited:

10 Apr 2014 01:21

Last Modified:

27 Jan 2015 04:16

Publisher DOI:

10.1097/MAT.0b013e31818b3d93

PubMed ID:

19033768

Uncontrolled Keywords:

Aortic Valve, Heart Valve Prosthesis, Hemodynamics, Prosthesis Design

BORIS DOI:

10.7892/boris.50103

URI:

https://boris.unibe.ch/id/eprint/50103

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