Intussusceptive microvascular growth: a common alternative to capillary sprouting.

Patan, S.; Alvarez, M. J.; Schittny, J.; Burri, P. H. (1992). Intussusceptive microvascular growth: a common alternative to capillary sprouting. Archives of histology and cytology, 55 Suppl, pp. 65-75.

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Intussusceptive capillary growth represents a new principle for microvascular growth as described in the lungs of growing rats. According to this concept, the capillary network expands by the formation of slender transcapillary tissue pillars, which give rise to new vascular meshes. The process was first observed in Mercox casts of the lung microvasculature, which revealed the existence of multiple tiny holes with diameters around 1.5 microns. Consecutive transmission electron microscopic investigation of serial sections demonstrated that the holes corresponded to slender tissue pillars (Burri and Tarek, 1990). The corrosion cast technique thus appears to be an adequate screening method for intussusceptive growth. In the present investigation, Mercox casts of various vascular systems, namely, those of the eye, submandibular gland, heart, liver, stomach, small and large intestine, trachea, kidney, uterus and ovary were prepared from rats aged between 4 and 9 weeks in order to screen them for the existence of the typical tiny holes representing tissue pillars. In all organs investigated, these structures were observed in various locations to a variable degree. They were mainly encountered within dilated vascular segments or at triple or quadruple branching points of the circulation. Even in capillary networks with a three-dimensional arrangement could these pillars be detected. Intussusception thus appears to be a principle of growth appertaining to many vascular systems.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Functional Anatomy
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy

UniBE Contributor:

Schittny, Johannes and Burri, Peter Hermann

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0914-9465

Submitter:

Johannes Schittny

Date Deposited:

18 Aug 2014 14:00

Last Modified:

18 Aug 2014 14:00

PubMed ID:

1290678

URI:

https://boris.unibe.ch/id/eprint/50167

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