Incidence of hypo- and hyper-capnia in a cross-sectional European cohort of ventilated newborn infants

van Kaam, Anton H.; De Jaegere, Anne P.; Rimensberger, Peter C.; the Neovent study group, on behalf of; Riedel, Thomas (2013). Incidence of hypo- and hyper-capnia in a cross-sectional European cohort of ventilated newborn infants. Archives of disease in childhood - fetal and neonatal edition, 98(4), F323-F326. BMJ Publishing Group 10.1136/archdischild-2012-302649

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OBJECTIVE

To determine the incidence of hypo- and hyper-capnia in a European cohort of ventilated newborn infants.

DESIGN AND SETTING

Two-point cross-sectional prospective study in 173 European neonatal intensive care units.

PATIENTS AND METHODS

Patient characteristics, ventilator settings and measurements, and blood gas analyses were collected for endotracheally ventilated newborn infants on two separate dates.

RESULTS

A total of 1569 blood gas analyses were performed in 508 included patients with a mean±SD Pco2 of 48±12 mm Hg or 6.4±1.6 kPa (range 17-104 mm Hg or 2.3-13.9 kPa). Hypocapnia (Pco2<30 mm Hg or 4 kPa) and hypercapnia (Pco2>52 mm Hg or 7 kPa) was present in, respectively, 69 (4%) and 492 (31%) of the blood gases. Hypocapnia was most common in the first 3 days of life (7.3%) and hypercapnia after the first week of life (42.6%). Pco2 was significantly higher in preterm infants (49 mm Hg or 6.5 kPa) than term infants (43 mm Hg or 5.7 kPa) and significantly lower during pressure-limited ventilation (47 mm Hg or 6.3±1.6 kPa) compared with volume-targeted ventilation (51 mm Hg or 6.8±1.7 kPa) and high-frequency ventilation (50 mm Hg or 6.7±1.7 kPa).

CONCLUSIONS

This study shows that hypocapnia is a relatively uncommon finding during neonatal ventilation. The higher incidence of hypercapnia may suggest that permissive hypercapnia has found its way into daily clinical practice.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Neonatology

UniBE Contributor:

Riedel, Thomas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1359-2998

Publisher:

BMJ Publishing Group

Language:

English

Submitter:

André Schaller

Date Deposited:

23 Apr 2014 11:07

Last Modified:

23 Apr 2014 11:07

Publisher DOI:

10.1136/archdischild-2012-302649

PubMed ID:

23241364

Uncontrolled Keywords:

hypercapnia, hypocapnia, mechanical ventilation, survey

URI:

https://boris.unibe.ch/id/eprint/50249

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