Evaluation of 9 biomarkers for predicting 10-year cardiovascular risk in patients undergoing coronary angiography: findings from the LUdwigshafen RIsk and Cardiovascular Health (LURIC) study.

Omicron Hartaigh, Bríain; Thomas, G Neil; Bosch, Jos A; Hemming, Karla; Pilz, Stefan; Loerbroks, Adrian; Kleber, Marcus E; Grammer, Tanja B; Fischer, Joachim E; Silbernagel, Günther; Tomaschitz, Andreas; März, Winfried (2013). Evaluation of 9 biomarkers for predicting 10-year cardiovascular risk in patients undergoing coronary angiography: findings from the LUdwigshafen RIsk and Cardiovascular Health (LURIC) study. International journal of cardiology, 168(3), pp. 2609-2615. Elsevier 10.1016/j.ijcard.2013.03.043

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BACKGROUND

Conventional factors do not fully explain the distribution of cardiovascular outcomes. Biomarkers are known to participate in well-established pathways associated with cardiovascular disease, and may therefore provide further information over and above conventional risk factors. This study sought to determine whether individual and/or combined assessment of 9 biomarkers improved discrimination, calibration and reclassification of cardiovascular mortality.

METHODS

3267 patients (2283 men), aged 18-95 years, at intermediate-to-high-risk of cardiovascular disease were followed in this prospective cohort study. Conventional risk factors and biomarkers were included based on forward and backward Cox proportional stepwise selection models.

RESULTS

During 10-years of follow-up, 546 fatal cardiovascular events occurred. Four biomarkers (interleukin-6, neutrophils, von Willebrand factor, and 25-hydroxyvitamin D) were retained during stepwise selection procedures for subsequent analyses. Simultaneous inclusion of these biomarkers significantly improved discrimination as measured by the C-index (0.78, P = 0.0001), and integrated discrimination improvement (0.0219, P<0.0001). Collectively, these biomarkers improved net reclassification for cardiovascular death by 10.6% (P<0.0001) when added to the conventional risk model.

CONCLUSIONS

In terms of adverse cardiovascular prognosis, a biomarker panel consisting of interleukin-6, neutrophils, von Willebrand factor, and 25-hydroxyvitamin D offered significant incremental value beyond that conveyed by simple conventional risk factors.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Angiology
UniBE Contributor:	Silbernagel, Günther
Subjects:	600 Technology > 610 Medicine & health
ISSN:	0167-5273
Publisher:	Elsevier
Language:	English
Submitter:	Catherine Gut
Date Deposited:	08 Jul 2014 09:58
Last Modified:	05 Dec 2022 14:33
Publisher DOI:	10.1016/j.ijcard.2013.03.043
PubMed ID:	23601216
Uncontrolled Keywords:	Biomarker, Cardiovascular, Discrimination, Reclassification, Risk factor
URI:	https://boris.unibe.ch/id/eprint/50725