Restenosis after infrapopliteal angioplasty - clinical importance, study update and further directions.

Baumann, Frederic; Diehm, Nicolas (2013). Restenosis after infrapopliteal angioplasty - clinical importance, study update and further directions. Vasa - European journal of vascular medicine, 42(6), pp. 413-420. Huber 10.1024/0301-1526/a000310

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Patients with critical limb ischemia (CLI) represent the most severe form of peripheral arterial disease (PAD) and exhibit high mortality rates. Frequently, PAD in CLI patients involves the infrapopliteal arterial segment challenging endovascular revascularization strategies. Restenosis remains the major drawback of tibial angioplasty encountered in more than two thirds of CLI patients undergoing tibial revascularization. In contrast to earlier observations, tibial patency was recently shown to be essential to attain an optimal clinical outcome in CLI patients subsequent to tibial angioplasty. The exact pathopyhsiological mechanisms of tibial restenosis remains unclear. To date, most of our knowledge on tibial restenosis and its pathophysiology is derived from coronary arteries, based on the similarity of coronary arteries to tibial artery morphology. Nervertheless, multiple antirestenosis concepts are investigated within clinical trials to reduce tibial restenosis.Purpose of the present manuscript is to provide a current update on the pathophysiology of tibial restenosis and potential antirestenosis strategies.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Angiology

UniBE Contributor:

Diehm, Nicolas Alexander

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0301-1526

Publisher:

Huber

Language:

English

Submitter:

Catherine Gut

Date Deposited:

09 Jul 2014 15:31

Last Modified:

09 Jul 2014 15:31

Publisher DOI:

10.1024/0301-1526/a000310

PubMed ID:

24220117

Uncontrolled Keywords:

Tibial angioplasty, antirestenosis, restenosis

URI:

https://boris.unibe.ch/id/eprint/50748

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