Ultrasound-assisted thrombolysis for acute pulmonary embolism: a systematic review.

Engelberger, Rolf Peter; Kucher, Nils (2014). Ultrasound-assisted thrombolysis for acute pulmonary embolism: a systematic review. European Heart Journal, 35(12), pp. 758-764. Oxford University Press 10.1093/eurheartj/ehu029

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Pulmonary embolism remains a common and potentially life-threatening disease. For patients with intermediate- and high-risk pulmonary embolism, catheter-based revascularization therapy has emerged as potential alternative to systemic thrombolysis or surgical embolectomy. Ultrasound-assisted catheter-directed thrombolysis is a contemporary catheter-based technique and is the focus of the present review. Ultrasound-assisted catheter-directed thrombolysis is more effective in reversing right ventricular dysfunction and dilatation in comparison with anticoagulation alone in patients at intermediate risk. However, a direct comparison of ultrasound-assisted thrombolysis with systemic thrombolysis or surgical thrombectomy is not available. Ultrasound-assisted thrombolysis with initial intrapulmonary thrombolytic bolus may also be effective in high-risk patients, but evidence from randomized trials is not available. This review summarizes current data on ultrasound-assisted thrombolysis for acute pulmonary embolism.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Angiology

UniBE Contributor:

Engelberger, Rolf Peter and Kucher, Nils

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0195-668X

Publisher:

Oxford University Press

Language:

English

Submitter:

Catherine Gut

Date Deposited:

09 Oct 2014 09:51

Last Modified:

27 Apr 2018 09:37

Publisher DOI:

10.1093/eurheartj/ehu029

PubMed ID:

24497337

Uncontrolled Keywords:

Bleeding, Catheter-based revascularization, Pulmonary embolism, Ultrasound-assisted thrombolysis

BORIS DOI:

10.7892/boris.50760

URI:

https://boris.unibe.ch/id/eprint/50760

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