Tailored protection against plasmalemmal injury by annexins with different Ca2+ sensitivities

Potez, Sarah; Luginbühl, Miriam; Monastyrskaya, Katia; Hostettler, Andrea; Draeger, Annette; Babiychuk, Eduard B (2011). Tailored protection against plasmalemmal injury by annexins with different Ca2+ sensitivities. Journal of biological chemistry, 286(20), pp. 17982-91. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M110.187625

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The annexins, a family of Ca(2+)- and lipid-binding proteins, are involved in a range of intracellular processes. Recent findings have implicated annexin A1 in the resealing of plasmalemmal injuries. Here, we demonstrate that another member of the annexin protein family, annexin A6, is also involved in the repair of plasmalemmal lesions induced by a bacterial pore-forming toxin, streptolysin O. An injury-induced elevation in the intracellular concentration of Ca(2+) ([Ca(2+)](i)) triggers plasmalemmal repair. The highly Ca(2+)-sensitive annexin A6 responds faster than annexin A1 to [Ca(2+)](i) elevation. Correspondingly, a limited plasmalemmal injury can be promptly countered by annexin A6 even without the participation of annexin A1. However, its high Ca(2+) sensitivity makes annexin A6 highly amenable to an unproductive binding to the uninjured plasmalemma; during an extensive injury accompanied by a massive elevation in [Ca(2+)](i), its active pool is severely depleted. In contrast, annexin A1 with a much lower Ca(2+) sensitivity is ineffective at the early stages of injury; however, it remains available for the repair even at high [Ca(2+)](i). Our findings highlight the role of the annexins in the process of plasmalemmal repair; a number of annexins with different Ca(2+)-sensitivities provide a cell with the means to react promptly to a limited injury in its early stages and, at the same time, to withstand a sustained injury accompanied by the continuous formation of plasmalemmal lesions.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Cell Biology
UniBE Contributor:	Potez, Sarah, Babiichuk, Eduard
ISSN:	0021-9258
Publisher:	American Society for Biochemistry and Molecular Biology
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:17
Last Modified:	02 Mar 2023 23:20
Publisher DOI:	10.1074/jbc.M110.187625
PubMed ID:	21454475
Web of Science ID:	000290585200060
URI:	https://boris.unibe.ch/id/eprint/5112 (FactScience: 209830)