Plasma membrane repair and cellular damage control: the annexin survival kit

Draeger, Annette; Monastyrskaya-Stäuber, Katia; Babiychuk, Eduard B (2011). Plasma membrane repair and cellular damage control: the annexin survival kit. Biochemical pharmacology, 81(6), pp. 703-12. New York, N.Y.: Elsevier 10.1016/j.bcp.2010.12.027

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Plasmalemmal injury is a frequent event in the life of a cell. Physical disruption of the plasma membrane is common in cells that operate under conditions of mechanical stress. The permeability barrier can also be breached by chemical means: pathogens gain access to host cells by secreting pore-forming toxins and phospholipases, and the host's own immune system employs pore-forming proteins to eliminate both pathogens and the pathogen-invaded cells. In all cases, the influx of extracellular Ca(2+) is being sensed and interpreted as an "immediate danger" signal. Various Ca(2+)-dependent mechanisms are employed to enable plasma membrane repair. Extensively damaged regions of the plasma membrane can be patched with internal membranes delivered to the cell surface by exocytosis. Nucleated cells are capable of resealing their injured plasmalemma by endocytosis of the permeabilized site. Likewise, the shedding of membrane microparticles is thought to be involved in the physical elimination of pores. Membrane blebbing is a further damage-control mechanism, which is triggered after initial attempts at plasmalemmal resealing have failed. The members of the annexin protein family are ubiquitously expressed and function as intracellular Ca(2+) sensors. Most cells contain multiple annexins, which interact with distinct plasma membrane regions promoting membrane segregation, membrane fusion and--in combination with their individual Ca(2+)-sensitivity--allow spatially confined, graded responses to membrane injury.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Cell Biology 04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy
UniBE Contributor:	Draeger, Annette, Monastyrskaya-Stäuber, Katia, Babiichuk, Eduard
Subjects:	600 Technology > 610 Medicine & health
ISSN:	0006-2952
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:17
Last Modified:	02 Mar 2023 23:20
Publisher DOI:	10.1016/j.bcp.2010.12.027
PubMed ID:	21219882
Web of Science ID:	000287996900002
URI:	https://boris.unibe.ch/id/eprint/5113 (FactScience: 209831)