Intussusceptive angiogenesis: pillars against the blood flow

Styp-Rekowska, B; Hlushchuk, R; Pries, A R; Djonov, V (2011). Intussusceptive angiogenesis: pillars against the blood flow. Acta physiologica, 202(3), pp. 213-23. Oxford: Blackwell Publishing 10.1111/j.1748-1716.2011.02321.x

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Adaptation of vascular networks to functional demands needs vessel growth, vessel regression and vascular remodelling. Biomechanical forces resulting from blood flow play a key role in these processes. It is well-known that metabolic stimuli, mechanical forces and flow patterns can affect gene expression and remodelling of vascular networks in different ways. For instance, in the sprouting type of angiogenesis related to hypoxia, there is no blood flow in the rising capillary sprout. In contrast, it has been shown that an increase of wall shear stress initiates the splitting type of angiogenesis in skeletal muscle. Otherwise, during development, both sprouting and intussusception act in parallel in building the vascular network, although with differences in spatiotemporal distribution. Thereby, in addition to regulatory molecules, flow dynamics support the patterning and remodelling of the rising vascular tree. Herewith, we present an overview of angiogenic processes with respect to intussusceptive angiogenesis as related to local haemodynamics.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Topographical and Clinical Anatomy

UniBE Contributor:

Styp, Beata; Hlushchuk, Ruslan and Djonov, Valentin Georgiev


600 Technology > 610 Medicine & health




Blackwell Publishing




Factscience Import

Date Deposited:

04 Oct 2013 14:17

Last Modified:

28 Dec 2020 07:54

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URI: (FactScience: 209851)

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