The role of postoperative prophylactic antibiotics in the treatment of facial fractures: a randomised, double-blind, placebo-controlled pilot clinical study. Part 3: Le Fort and zygomatic fractures in 94 patients

Soong, Poh Luon; Schaller, Benoit; Zix, Jürgen; Iizuka, Tateyuki; Mottini, Matthias; Lieger, Olivier (2014). The role of postoperative prophylactic antibiotics in the treatment of facial fractures: a randomised, double-blind, placebo-controlled pilot clinical study. Part 3: Le Fort and zygomatic fractures in 94 patients. British journal of oral & maxillofacial surgery, 52(4), pp. 329-333. Elsevier 10.1016/j.bjoms.2014.01.010

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The aim of this study was to evaluate the difference between the effect of a 5-day and a 1-day postoperative course of antibiotics on the incidence of infection after midfacial fractures. A total of 98 patients with displaced Le Fort or zygomatic fractures that required operation were randomly assigned into 2 groups, both of which were given amoxicillin/clavulanic acid 1.2g intravenously every 8h from the time of admission until 24h postoperatively. The 5-day group was then given amoxicillin/clavulanic acid 625mg orally 8-hourly for another 4 days. The 1-day group was given placebo orally at the same time points. Patients were followed up 1, 2, 4, 6, and 12 weeks, and 6 months, postoperatively. The development of an infection of the wound was the primary end point. Ninety-four of the 98 patients completed the study. Two of the 45 patients in the 5-day group (4%) and 2/49 in the 1-day group (4%) developed postoperative wound infections. One in each group had a purulent infection, while the others had only wound breakdown. Two patients of the 5-day group and one in the 1-day group developed rashes on the trunk. There were no significant differences in the incidence of infection or side effects between the groups. In midfacial fractures a 1-day course of antibiotics postoperatively is as effective in preventing infective complications as a 5-day regimen.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Craniomaxillofacial Surgery

UniBE Contributor:

Iizuka, Tateyuki; Mottini, Matthias and Lieger, Olivier

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0266-4356

Publisher:

Elsevier

Language:

English

Submitter:

Caroline Dominique Zürcher

Date Deposited:

06 Oct 2014 14:00

Last Modified:

05 Nov 2015 11:48

Publisher DOI:

10.1016/j.bjoms.2014.01.010

PubMed ID:

24602602

Uncontrolled Keywords:

Zygoma, Zygomatic fracture, Midface fractures, Le Fort, Antibiotics, Antimicrobial agents, Infection

BORIS DOI:

10.7892/boris.51444

URI:

https://boris.unibe.ch/id/eprint/51444

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