Development of dendritic tonic GABAergic inhibition regulates excitability and plasticity in CA1 pyramidal neurons

Groen, M. R.; Paulsen, O.; Pérez Garci, Enrique; Nevian, Thomas; Wortel, J.; Dekker, M. P.; Mansvelder, H. D.; van Ooyen, A.; Meredith, R. M. (2014). Development of dendritic tonic GABAergic inhibition regulates excitability and plasticity in CA1 pyramidal neurons. Journal of neurophysiology, 112(2), pp. 287-299. American Physiological Society 10.1152/jn.00066.2014

[img] Text
Goen_Meredith_2014_JNeurophysiol.pdf - Accepted Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (1MB) | Request a copy

Synaptic plasticity rules change during development: while hippocampal synapses can be potentiated by a single action potential pairing protocol in young neurons, mature neurons require burst firing to induce synaptic potentiation. An essential component for spike timing-dependent plasticity is the backpropagating action potential (BAP). BAP along the dendrites can be modulated by morphology and ion channel composition, both of which change during late postnatal development. However it is unclear whether these dendritic changes can explain the developmental changes in synaptic plasticity induction rules. Here, we show that tonic GABAergic inhibition regulates dendritic action potential backpropagation in adolescent but not pre-adolescent CA1 pyramidal neurons. These developmental changes in tonic inhibition also altered the induction threshold for spike timing-dependent plasticity in adolescent neurons. This GABAergic regulatory effect upon backpropagation is restricted to distal regions of apical dendrites (>200 μm) and mediated by α5-containing GABA(A) receptors. Direct dendritic recordings demonstrate α5-mediated tonic GABA(A) currents in adolescent neurons which can modulate backpropagating action potentials. These developmental modulations in dendritic excitability could not be explained by concurrent changes in dendritic morphology. To explain our data, model simulations propose a distally-increasing or localized distal expression of dendritic α5 tonic inhibition in mature neurons. Overall, our results demonstrate that dendritic integration and plasticity in more mature dendrites are significantly altered by tonic α5 inhibition in a dendritic region-specific and developmentally-regulated manner.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Physiology

UniBE Contributor:

Pérez Garci, Enrique and Nevian, Thomas

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

0022-3077

Publisher:

American Physiological Society

Language:

English

Submitter:

Stefan von Känel-Zimmermann

Date Deposited:

13 Jun 2014 13:43

Last Modified:

06 Dec 2014 06:03

Publisher DOI:

10.1152/jn.00066.2014

BORIS DOI:

10.7892/boris.51711

URI:

https://boris.unibe.ch/id/eprint/51711

Actions (login required)

Edit item Edit item
Provide Feedback