Antimicrobial susceptibility of canine Clostridium perfringens strains from Switzerland

Gobeli, S.; Berset, C.; Burgener, I.; Perreten, V. (2012). Antimicrobial susceptibility of canine Clostridium perfringens strains from Switzerland. Schweizer Archiv für Tierheilkunde, 154(6), pp. 247-250. Huber 10.1024/0036-7281/a000340

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Fifty Clostridium perfringens strains were isolated from individual dogs with acute diarrhoea that were not given antibiotics. Toxin types and minimal inhibitory concentrations of 15 antibiotics were determined for each of them. All strains harboured the alpha-toxin gene, 12 of them had both the alpha- and entero-toxin gene and 5 had both the alpha- and beta2-toxin gene. Eighteen percent of the isolates showed resistance to tetracycline and 54 % showed decreased susceptibility to metronidazole which is one of the most frequently used antibiotics in the treatment of canine diarrhoea. Apart from that, all isolates were susceptible to the remaining antibiotics tested. These findings lead to the conclusion that despite a general susceptibility to antibiotics in C. perfringens, resistance is developing in isolates from dogs. Therefore, careful identification of the pathogenic agent and antibiotic susceptibility testing should be performed prior to therapy in order to minimise further selection of antibiotic resistance.

Item Type:	Journal Article (Original Article)
Division/Institute:	05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Veterinary Bacteriology > Molecular Bacterial Epidemiology and Infectiology 05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction 05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Veterinary Bacteriology
UniBE Contributor:	Gobeli, Stefanie, Burgener, Iwan, Perreten, Vincent
Subjects:	500 Science > 570 Life sciences; biology 600 Technology > 630 Agriculture
ISSN:	0036-7281
Publisher:	Huber
Language:	English
Submitter:	Vincent Perreten
Date Deposited:	30 Apr 2014 16:09
Last Modified:	05 Dec 2022 14:34
Publisher DOI:	10.1024/0036-7281/a000340
PubMed ID:	22653699
URI:	https://boris.unibe.ch/id/eprint/52014