Small multidrug resistance plasmids in Actinobacillus porcitonsillarum

Matter, Denise; Rossano, Alexandra; Sieber, Sandra; Perreten, Vincent (2008). Small multidrug resistance plasmids in Actinobacillus porcitonsillarum. Plasmid, 59(2), pp. 144-152. Elsevier 10.1016/j.plasmid.2007.11.003

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The complete nucleotide sequences of six Actinobacillus porcitonsillarum plasmids pKMA202 (13.425-kb), pKMA1467 (11.115-kb), pKMA5 (9.549-kb), pIMD50 (8.751-kb), pKMA505 (8.632-kb) and pKMA757 (4.556-kb) and three Actinobacillus pleuropneumoniae plasmids pPSAS1522 (4.244-kb), pARD3079 (3.884-kb) and pKMA2425 (3.156-kb) were determined. All the plasmids contain the sulfonamide resistance gene sul2. One A. pleuropneumoniae plasmid and five A. porcitonsillarum plasmids also have the streptomycin resistance gene strA. Among these latter five A. porcitonsillarum plasmids, four also harbor the beta-lactam resistance gene bla(ROB-1). This study is the first report of multidrug resistance plasmids in the non-pathogenic A. porcitonsillarum.

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