Mdt(A), a new efflux protein conferring multiple antibiotic resistance in Lactococcus lactis and Escherichia coli

Perreten, Vincent; Schwarz, Franziska V.; Teuber, Michael; Levy, Stuart B. (2001). Mdt(A), a new efflux protein conferring multiple antibiotic resistance in Lactococcus lactis and Escherichia coli. Antimicrobial agents and chemotherapy, 45(4), pp. 1109-1114. American Society for Microbiology 10.1128/AAC.45.4.1109-1114.2001

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The mdt(A) gene, previously designated mef214, from Lactococcus lactis subsp. lactis plasmid pK214 encodes a protein [Mdt(A) (multiple drug transporter)] with 12 putative transmembrane segments (TMS) that contain typical motifs conserved among the efflux proteins of the major facilitator superfamily. However, it also has two C-motifs (conserved in the fifth TMS of the antiporters) and a putative ATP-binding site. Expression of the cloned mdt(A) gene decreased susceptibility to macrolides, lincosamides, streptogramins, and tetracyclines in L. lactis and Escherichia coli, but not in Enterococcus faecalis or in Staphylococcus aureus. Glucose-dependent efflux of erythromycin and tetracycline was demonstrated in L. lactis and in E. coli.

Item Type:	Journal Article (Original Article)
Division/Institute:	05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Veterinary Bacteriology
UniBE Contributor:	Perreten, Vincent
Subjects:	500 Science 500 Science > 570 Life sciences; biology 600 Technology > 630 Agriculture
ISSN:	0066-4804
Publisher:	American Society for Microbiology
Language:	English
Submitter:	Vincent Perreten
Date Deposited:	01 Sep 2014 09:15
Last Modified:	05 Dec 2022 14:34
Publisher DOI:	10.1128/AAC.45.4.1109-1114.2001
PubMed ID:	11257023
URI:	https://boris.unibe.ch/id/eprint/52027