Hemodynamics and Flow Characteristics of a New Dialysis Port

Guignard, Jérémie; Terefe, Muluken Berhanu; Uehlinger, Dominik; Czerwinska, Justyna (2014). Hemodynamics and Flow Characteristics of a New Dialysis Port. ASAIO journal, 60(1), pp. 81-89. Lippincott Williams & Wilkins 10.1097/MAT.0000000000000015

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Renal replacement therapy by hemodialysis requires a permanent vascular access. Implantable ports offer a potential alternative to standard vascular access strategies although their development is limited both in number and extent. We explored the fluid dynamics within two new percutaneous bone-anchored dialysis port prototypes, both by in vitro experiments and computer simulation. The new port is to be fixed to bone and allows the connection of a dialysis machine to a central venous catheter via a built-in valve. We found that the pressure drop induced by the two ports was between 20 and 50 mmHg at 500 ml/min, which is comparable with commercial catheter connectors (15–80 mmHg). We observed the formation of vortices in both geometries, and a shear rate in the physiological range (<10,000s-1), which is lower than maximal shear rates reported in commercial catheters (up to 13,000s-1). A difference in surface shear rate of 15% between the two ports was obtained.

Item Type:

Journal Article (Original Article)

Division/Institute:

10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Artificial Kidney Research
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension

UniBE Contributor:

Guignard, Jérémie; Terefe, Muluken Berhanu; Uehlinger, Dominik and Czerwinska, Justyna

Subjects:

600 Technology > 620 Engineering

ISSN:

1058-2916

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Justyna Czerwinska

Date Deposited:

12 Sep 2014 09:06

Last Modified:

22 Oct 2015 14:18

Publisher DOI:

10.1097/MAT.0000000000000015

PubMed ID:

24335387

Uncontrolled Keywords:

dialysis port, hemodynamics, catheter, finite elements model

BORIS DOI:

10.7892/boris.52094

URI:

https://boris.unibe.ch/id/eprint/52094

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