Scaling relations between trabecular bone volume fraction and microstructure at different skeletal sites

Räth, Christoph; Baum, Thomas; Monetti, Roberto; Sidorenko, Irina; Wolf, Petra; Eckstein, Felix; Matsuura, Maiko; Lochmüller, Eva-Maria; Zysset, Philippe K.; Rummeny, Ernst J.; Link, Thomas M.; Bauer, Jan S. (2013). Scaling relations between trabecular bone volume fraction and microstructure at different skeletal sites. Bone, 57(2), pp. 377-383. Elsevier 10.1016/j.bone.2013.09.004

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In this study, we investigated the scaling relations between trabecular bone volume fraction (BV/TV) and parameters of the trabecular microstructure at different skeletal sites.

Cylindrical bone samples with a diameter of 8mm were harvested from different skeletal sites of 154 human donors in vitro: 87 from the distal radius, 59/69 from the thoracic/lumbar spine, 51 from the femoral neck, and 83 from the greater trochanter. μCT images were obtained with an isotropic spatial resolution of 26μm. BV/TV and trabecular microstructure parameters (TbN, TbTh, TbSp, scaling indices (< > and σ of α and αz), and Minkowski Functionals (Surface, Curvature, Euler)) were computed for each sample. The regression coefficient β was determined for each skeletal site as the slope of a linear fit in the double-logarithmic representations of the correlations of BV/TV versus the respective microstructure parameter.

Statistically significant correlation coefficients ranging from r=0.36 to r=0.97 were observed for BV/TV versus microstructure parameters, except for Curvature and Euler. The regression coefficients β were 0.19 to 0.23 (TbN), 0.21 to 0.30 (TbTh), −0.28 to −0.24 (TbSp), 0.58 to 0.71 (Surface) and 0.12 to 0.16 (<α>), 0.07 to 0.11 (<αz>), −0.44 to −0.30 (σ(α)), and −0.39 to −0.14 (σ(αz)) at the different skeletal sites. The 95% confidence intervals of β overlapped for almost all microstructure parameters at the different skeletal sites. The scaling relations were independent of vertebral fracture status and similar for subjects aged 60–69, 70–79, and >79years.

In conclusion, the bone volume fraction–microstructure scaling relations showed a rather universal character.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Pre-clinic Human Medicine > Institute for Surgical Technology & Biomechanics ISTB [discontinued]
UniBE Contributor:	Zysset, Philippe
Subjects:	500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health 600 Technology > 620 Engineering
ISSN:	8756-3282
Publisher:	Elsevier
Language:	English
Submitter:	Philippe Zysset
Date Deposited:	12 May 2014 09:44
Last Modified:	05 Dec 2022 14:34
Publisher DOI:	10.1016/j.bone.2013.09.004
URI:	https://boris.unibe.ch/id/eprint/52159