Lung cancer screening with CT: evaluation of radiologists and different computer assisted detection software (CAD) as first and second readers for lung nodule detection at different dose levels

Christe, Andreas; Leidolt, Lars; Huber, Adrian T.; Steiger, Philipp; Szucs-Farkas, Zsolt; Roos, J. E.; Heverhagen, J. T.; Ebner, Lukas M. (2013). Lung cancer screening with CT: evaluation of radiologists and different computer assisted detection software (CAD) as first and second readers for lung nodule detection at different dose levels. European journal of radiology, 82(12), e873-e878. Elsevier 10.1016/j.ejrad.2013.08.026

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OBJECTIVES To find the best pairing of first and second reader at highest sensitivity for detecting lung nodules with CT at various dose levels. MATERIALS AND METHODS An anthropomorphic lung phantom and artificial lung nodules were used to simulate screening CT-examination at standard dose (100 mAs, 120 kVp) and 8 different low dose levels, using 120, 100 and 80 kVp combined with 100, 50 and 25 mAs. At each dose level 40 phantoms were randomly filled with 75 solid and 25 ground glass nodules (5-12 mm). Two radiologists and 3 different computer aided detection softwares (CAD) were paired to find the highest sensitivity. RESULTS Sensitivities at standard dose were 92%, 90%, 84%, 79% and 73% for reader 1, 2, CAD1, CAD2, CAD3, respectively. Combined sensitivity for human readers 1 and 2 improved to 97%, (p1=0.063, p2=0.016). Highest sensitivities--between 97% and 99.0%--were achieved by combining any radiologist with any CAD at any dose level. Combining any two CADs, sensitivities between 85% and 88% were significantly lower than for radiologists combined with CAD (p<0.03). CONCLUSIONS Combination of a human observer with any of the tested CAD systems provide optimal sensitivity for lung nodule detection even at reduced dose at 25 mAs/80 kVp.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology

UniBE Contributor:

Christe, Andreas; Leidolt, Lars; Huber, Adrian Thomas; Steiger, Philipp; Szücs Farkas, Zsolt and Ebner, Lukas Michael

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0720-048X

Publisher:

Elsevier

Language:

English

Submitter:

Susanne Furrer

Date Deposited:

12 May 2014 08:50

Last Modified:

21 Mar 2016 10:28

Publisher DOI:

10.1016/j.ejrad.2013.08.026

PubMed ID:

24074648

Uncontrolled Keywords:

CAD, Ground glass nodule, Low-dose CT, Lung cancer screening, Lung nodules

URI:

https://boris.unibe.ch/id/eprint/52198

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