Heart transplantation with donation after circulatory determination of death.

Longnus, Sarah L.; Mathys, Veronika; Dornbierer, Monika; Dick, Florian; Carrel, Thierry; Tevaearai, Hendrik (2014). Heart transplantation with donation after circulatory determination of death. Nature reviews - cardiology, 11(6), pp. 354-363. Nature Publishing Group 10.1038/nrcardio.2014.45

Full text not available from this repository. (Request a copy)

The constant shortage of available organs is a major obstacle and limiting factor in heart transplantation; the discrepancy between the number of donors and potential recipients leads to waiting-list mortality of 10-12% per year in Europe and the USA. If adopted for heart transplantation, donation after circulatory determination of death (DCDD) would be expected to improve the availability of organs substantially for both adults and children. With DCDD, however, hearts to be transplanted undergo a period of warm ischaemia before procurement, which is of particular concern because tissue damage occurs rapidly and might be sufficient to preclude transplantation. Nonetheless, the heart is able to withstand limited periods of warm ischaemia, which could provide a window of opportunity for DCDD. Development of clinical approaches specifically for DCDD is critical for the exploitation of these organs, because current practices for donor heart procurement, evaluation, and storage have been optimized for conventional donation after brain death, without consideration of warm ischaemia before organ procurement. Establishment of clinical protocols and ethical and legal frameworks for DCDD of other organs is underway. This Review provides a timely evaluation of the potential for DCDD in heart transplantation.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Herz- und Gefässchirurgie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Herz- und Gefässchirurgie

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiovascular Surgery

UniBE Contributor:

Longnus, Sarah; Mathys, Veronika; Dornbierer, Monika; Dick, Florian; Carrel, Thierry and Tevaearai, Hendrik

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1759-5010

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Sara Baumberger

Date Deposited:

17 Feb 2015 09:01

Last Modified:

27 Oct 2015 11:29

Publisher DOI:

10.1038/nrcardio.2014.45

PubMed ID:

24736758

URI:

https://boris.unibe.ch/id/eprint/52608

Actions (login required)

Edit item Edit item
Provide Feedback