Stratification and compartmentalisation of immunoglobulin responses to commensal intestinal microbes

Macpherson, Andrew; McCoy, Kathleen (2013). Stratification and compartmentalisation of immunoglobulin responses to commensal intestinal microbes. Seminars in immunology, 25(5), pp. 358-363. W.B. Saunders 10.1016/j.smim.2013.09.004

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The gastrointestinal tract is heavily colonized with commensal microbes with the concentration of bacteria increasing longitudinally down the length of the intestine. Bacteria are also spatially distributed transversely from the epithelial surface to the intestinal lumen with the inner mucus layer normally void of bacteria. Maintenance of this equilibrium is extremely important for human health and, as the dominant immunoglobulin at mucosal sites, IgA influences mutualism between the host and its normal microbiota. In this review we focus on the links between immune and microbial geography of the mammalian intestinal tract.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology

UniBE Contributor:

Macpherson, Andrew and McCoy, Kathleen

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1044-5323

Publisher:

W.B. Saunders

Language:

English

Submitter:

Lilian Karin Smith-Wirth

Date Deposited:

12 Jun 2014 09:56

Last Modified:

06 Nov 2015 09:57

Publisher DOI:

10.1016/j.smim.2013.09.004

Uncontrolled Keywords:

Immunoglobulin A, Commensal bacteria, Intestinal mucus, Mucosal immunity, Intestinal homeostasis, Host-microbial superorganism

BORIS DOI:

10.7892/boris.53039

URI:

https://boris.unibe.ch/id/eprint/53039

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