Intestinal Microbial Diversity during Early-Life Colonization Shapes Long-Term IgE Levels

Cahenzli, Julia; Köller, Yasmin; Wyss, Madeleine; Geuking, Markus; McCoy, Kathleen (2013). Intestinal Microbial Diversity during Early-Life Colonization Shapes Long-Term IgE Levels. Cell host & microbe, 14(5), pp. 559-570. Cell Press 10.1016/j.chom.2013.10.004

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Microbial exposure following birth profoundly impacts mammalian immune system development. Microbiota alterations are associated with increased incidence of allergic and autoimmune disorders with elevated serum IgE as a hallmark. The previously reported abnormally high serum IgE levels in germ-free mice suggests that immunoregulatory signals from microbiota are required to control basal IgE levels. We report that germ-free mice and those with low-diversity microbiota develop elevated serum IgE levels in early life. B cells in neonatal germ-free mice undergo isotype switching to IgE at mucosal sites in a CD4 T-cell- and IL-4-dependent manner. A critical level of microbial diversity following birth is required in order to inhibit IgE induction. Elevated IgE levels in germ-free mice lead to increased mast-cell-surface-bound IgE and exaggerated oral-induced systemic anaphylaxis. Thus, appropriate intestinal microbial stimuli during early life are critical for inducing an immunoregulatory network that protects from induction of IgE at mucosal sites.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery

UniBE Contributor:

Cahenzli, Julia; Köller, Yasmin; Wyss, Madeleine; Geuking, Markus and McCoy, Kathleen

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1931-3128

Publisher:

Cell Press

Language:

English

Submitter:

Lilian Karin Smith-Wirth

Date Deposited:

16 Jun 2014 13:28

Last Modified:

14 Dec 2014 13:10

Publisher DOI:

10.1016/j.chom.2013.10.004

Related URLs:

BORIS DOI:

10.7892/boris.53040

URI:

https://boris.unibe.ch/id/eprint/53040

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