Intestinal bacteria induce TSLP to promote mutualistic T-cell responses

Mosconi, I.; Geuking, Markus; Zaiss, M. M.; Massacand, Jonathan; Aschwanden, C.; Kwong Chung, Cheong Kwet Choy; McCoy, Kathleen; Harris, N. L. (2013). Intestinal bacteria induce TSLP to promote mutualistic T-cell responses. Mucosal immunology, 6(6), pp. 1157-1167. Nature Publishing Group 10.1038/mi.2013.12

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Thymic stromal lymphopoietin (TSLP) is constitutively expressed in the intestine and is known to regulate inflammation in models of colitis. We show that steady-state TSLP expression requires intestinal bacteria and has an important role in limiting the expansion of colonic T helper type 17 (Th17) cells. Inappropriate expansion of the colonic Th17 cells occurred in response to an entirely benign intestinal microbiota, as determined following the colonization of germ-free C57BL/6 or TSLPR(-/-) mice with the altered Schaedler flora (ASF). TSLP-TSLPR (TSLP receptor) interactions also promoted the expansion of colonic Helios(-)Foxp3(+) regulatory T cells, necessary for the control of inappropriate Th17 responses following ASF bacterial colonization. In summary, these data reveal an important role for TSLP-TSLPR signaling in promoting steady-state mutualistic T-cell responses following intestinal bacterial colonization.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery

UniBE Contributor:

Geuking, Markus; Kwong Chung, Cheong Kwet Choy and McCoy, Kathleen

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1933-0219

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Lilian Karin Smith-Wirth

Date Deposited:

16 Jun 2014 07:59

Last Modified:

06 Nov 2015 09:50

Publisher DOI:

10.1038/mi.2013.12

BORIS DOI:

10.7892/boris.53043

URI:

https://boris.unibe.ch/id/eprint/53043

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