Microbial-immune cross-talk and regulation of the immune system

Cahenzli, Julia; Balmer, Maria Luisa; McCoy, Kathleen (2012). Microbial-immune cross-talk and regulation of the immune system. Immunology, 138(1), pp. 12-22. Wiley-Blackwell 10.1111/j.1365-2567.2012.03624.x

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We are all born germ-free. Following birth we enter into a lifelong relationship with microbes residing on our body's surfaces. The lower intestine is home to the highest microbial density in our body, which is also the highest microbial density known on Earth (up to 10(12) /g of luminal contents). With our indigenous microbial cells outnumbering our human cells by an order of magnitude our body is more microbial than human. Numerous immune adaptations confine these microbes within the mucosa, enabling most of us to live in peaceful homeostasis with our intestinal symbionts. Intestinal epithelial cells not only form a physical barrier between the bacteria-laden lumen and the rest of the body but also function as multi-tasking immune cells that sense the prevailing microbial (apical) and immune (basolateral) milieus, instruct the underlying immune cells, and adapt functionally. In the constant effort to ensure intestinal homeostasis, the immune system becomes educated to respond appropriately and in turn immune status can shape the microbial consortia. Here we review how the dynamic immune-microbial dialogue underlies maturation and regulation of the immune system and discuss recent findings on the impact of diet on both microbial ecology and immune function.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie

UniBE Contributor:

Cahenzli, Julia; Balmer, Maria Luisa and McCoy, Kathleen

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0019-2805

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Lilian Karin Smith-Wirth

Date Deposited:

27 Jun 2014 09:42

Last Modified:

14 Dec 2014 13:19

Publisher DOI:

10.1111/j.1365-2567.2012.03624.x

Uncontrolled Keywords:

immunoglobulin A, innate lymphoid cells, intestinal epithelium, intestinal microbiota

BORIS DOI:

10.7892/boris.53045

URI:

https://boris.unibe.ch/id/eprint/53045

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