Hypertrophy of infected Peyer’s patches arises from global, interferon-receptor, and CD69-independent shutdown of lymphocyte egress

Schulz, O.; Ugur, M.; Friedrichsen, M.; Radulovic, K.; Niess, Jan Hendrik; Jalkanen, S.; Krueger, A.; Pabst, O. (2014). Hypertrophy of infected Peyer’s patches arises from global, interferon-receptor, and CD69-independent shutdown of lymphocyte egress. Mucosal immunology, 7(4), pp. 892-904. Nature Publishing Group 10.1038/mi.2013.105

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Lymphoid organ hypertrophy is a hallmark of localized infection. During the inflammatory response, massive changes in lymphocyte recirculation and turnover boost lymphoid organ cellularity. Intriguingly, the exact nature of these changes remains undefined to date. Here, we report that hypertrophy of Salmonella-infected Peyer's patches (PPs) ensues from a global "shutdown" of lymphocyte egress, which traps recirculating lymphocytes in PPs. Surprisingly, infection-induced lymphocyte sequestration did not require previously proposed mediators of lymphoid organ shutdown including type I interferon receptor and CD69. In contrast, following T-cell receptor-mediated priming, CD69 was essential to selectively block CD4+ effector T-cell egress. Our findings segregate two distinct lymphocyte sequestration mechanisms, which differentially rely on intrinsic modulation of lymphocyte egress capacity and inflammation-induced changes in the lymphoid organ environment.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology

UniBE Contributor:

Niess, Jan Hendrik

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1933-0219

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Lilian Karin Smith-Wirth

Date Deposited:

11 Jun 2014 15:32

Last Modified:

05 Dec 2014 04:31

Publisher DOI:

10.1038/mi.2013.105

BORIS DOI:

10.7892/boris.53047

URI:

https://boris.unibe.ch/id/eprint/53047

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