RNA duplexes with biphenyl substituents as base replacements are less stable than DNA duplexes

Brotschi, Christine; Leumann, Christian J. (2005). RNA duplexes with biphenyl substituents as base replacements are less stable than DNA duplexes. Chemical communications(15), pp. 2023-2025. Royal Society of Chemistry 10.1039/B419278H

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Introduction of a hydrophobic biphenyl-C-nucleotide pair into a 11-mer RNA duplex is associated with a net penalty in the free energy of duplex formation of 2.0 kcal mol(-1) or 10 degrees C in T(m), relative to DNA. These differential stabilities are of relevance with respect to the transcriptional and translational aspects of hydrophobic base-pairs

Item Type:

Journal Article (Further Contribution)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Leumann, Christian

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

1359-7345

Publisher:

Royal Society of Chemistry

Language:

English

Submitter:

Christian Leumann

Date Deposited:

26 May 2014 14:44

Last Modified:

10 Aug 2015 10:46

Publisher DOI:

10.1039/B419278H

PubMed ID:

15834493

Uncontrolled Keywords:

base, BASE-PAIR, biphenyl, DNA, duplex, DUPLEXES, RNA, stability

BORIS DOI:

10.7892/boris.53097

URI:

https://boris.unibe.ch/id/eprint/53097

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