Tuning Molecular Recognition of RNA and DNA via Sugar Modification

Leumann, Christian J. (2005). Tuning Molecular Recognition of RNA and DNA via Sugar Modification. CHIMIA, 59(11), pp. 776-779. Bern: Schweizerische Chemische Gesellschaft

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This minireview highlights three aspects of our recent work in the area of sugar modified oligonucleotide analogues. It provides an overview over recent results on the conformationally constrained analogue tricyclo-DNA with special emphasis of its antisense properties, it summarizes results on triple-helix forming oligodeoxynucleotides containing pyrrolidino-nucleosides with respect to DNA recognition via the dual recognition mode, and it highlights the advantageous application of the orthogonal oligonucleotidic pairing system homo-DNA in molecular beacons for DNA diagnostics

Item Type:

Journal Article (Review Article)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Leumann, Christian

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

0009-4293

Publisher:

Schweizerische Chemische Gesellschaft

Language:

English

Submitter:

Christian Leumann

Date Deposited:

26 May 2014 15:28

Last Modified:

04 Feb 2016 09:03

Uncontrolled Keywords:

analogue, analogues, Antisense, DNA, DNA recognition, Homo-DNA, modified, molecular, molecular beacons, molecular recognition, Oligodeoxynucleotides, oligonucleotide, properties, recognition, RNA, sugar, sugar modified, tricyclo-DNA, triple helix

BORIS DOI:

10.7892/boris.53107

URI:

https://boris.unibe.ch/id/eprint/53107

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