The Role of PTEN in Tumor Angiogenesis

Rodriguez, Stéphane; Huynh-Do, Uyen (2012). The Role of PTEN in Tumor Angiogenesis. Journal of oncology, 2012, p. 141236. Cairo (Egypt): Hindawi Publishing Corporation 10.1155/2012/141236

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During the past 20 years, the phosphatase and tensin homolog PTEN has been shown to be involved in major physiological processes, and its mutation or loss is often associated with tumor formation. In addition PTEN regulates angiogenesis not only through its antagonizing effect on the PI3 kinase pathway mainly, but also through some phosphatase-independent functions. In this paper we delineate the role of this powerful tumor suppressor in tumor angiogenesis and dissect the underlying molecular mechanisms. Furthermore, it appears that, in a number of cancers, the PTEN status determines the response to chemotherapy, highlighting the need to monitor PTEN expression and to develop PTEN-targeted therapies.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension

UniBE Contributor:

Rodriguez, Stéphane and Huynh-Do, Uyen

ISSN:

1687-8450

Publisher:

Hindawi Publishing Corporation

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:17

Last Modified:

08 Dec 2014 19:20

Publisher DOI:

10.1155/2012/141236

PubMed ID:

21904550

BORIS DOI:

10.7892/boris.5344

URI:

https://boris.unibe.ch/id/eprint/5344 (FactScience: 210084)

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