An index to identify stroke-related vs incidental patent foramen ovale in cryptogenic stroke

Kent, David M.; Ruthazer, Robin; Weimar, Christian; Mas, Jean-Louis; Serena, Joaquín; Homma, Shunichi; Di Angelantonio, Emanuele; Di Tullio, Marco R.; Lutz, Jennifer S.; Elkind, Mitchell S. V.; Griffith, John; Jaigobin, Cheryl; Mattle, Heinrich P.; Michel, Patrik; Mono, Marie-Luise; Nedeltchev, Krassen; Papetti, Federica; Thaler, David E. (2013). An index to identify stroke-related vs incidental patent foramen ovale in cryptogenic stroke. Neurology, 81(7), pp. 619-625. Lippincott Williams & Wilkins 10.1212/WNL.0b013e3182a08d59

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OBJECTIVE We aimed to create an index to stratify cryptogenic stroke (CS) patients with patent foramen ovale (PFO) by their likelihood that the stroke was related to their PFO. METHODS Using data from 12 component studies, we used generalized linear mixed models to predict the presence of PFO among patients with CS, and derive a simple index to stratify patients with CS. We estimated the stratum-specific PFO-attributable fraction and stratum-specific stroke/TIA recurrence rates. RESULTS Variables associated with a PFO in CS patients included younger age, the presence of a cortical stroke on neuroimaging, and the absence of these factors: diabetes, hypertension, smoking, and prior stroke or TIA. The 10-point Risk of Paradoxical Embolism score is calculated from these variables so that the youngest patients with superficial strokes and without vascular risk factors have the highest score. PFO prevalence increased from 23% (95% confidence interval [CI]: 19%-26%) in those with 0 to 3 points to 73% (95% CI: 66%-79%) in those with 9 or 10 points, corresponding to attributable fraction estimates of approximately 0% to 90%. Kaplan-Meier estimated stroke/TIA 2-year recurrence rates decreased from 20% (95% CI: 12%-28%) in the lowest Risk of Paradoxical Embolism score stratum to 2% (95% CI: 0%-4%) in the highest. CONCLUSION Clinical characteristics identify CS patients who vary markedly in PFO prevalence, reflecting clinically important variation in the probability that a discovered PFO is likely to be stroke-related vs incidental. Patients in strata more likely to have stroke-related PFOs have lower recurrence risk.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Mattle, Heinrich; Mono, Marie-Luise and Nedeltchev, Krassen

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0028-3878

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Valentina Rossetti

Date Deposited:

17 Jun 2014 09:33

Last Modified:

08 Feb 2015 23:06

Publisher DOI:

10.1212/WNL.0b013e3182a08d59

PubMed ID:

23864310

BORIS DOI:

10.7892/boris.53471

URI:

https://boris.unibe.ch/id/eprint/53471

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